[HTML][HTML] A single-cell atlas of the human substantia nigra reveals cell-specific pathways associated with neurological disorders
We describe a human single-nuclei transcriptomic atlas for the substantia nigra (SN),
generated by sequencing approximately 17,000 nuclei from matched cortical and SN …
generated by sequencing approximately 17,000 nuclei from matched cortical and SN …
[HTML][HTML] Single-cell genomic profiling of human dopamine neurons identifies a population that selectively degenerates in Parkinson's disease
T Kamath, A Abdulraouf, SJ Burris, J Langlieb… - Nature …, 2022 - nature.com
The loss of dopamine (DA) neurons within the substantia nigra pars compacta (SNpc) is a
defining pathological hallmark of Parkinson's disease (PD). Nevertheless, the molecular …
defining pathological hallmark of Parkinson's disease (PD). Nevertheless, the molecular …
Genetic identification of cell types underlying brain complex traits yields insights into the etiology of Parkinson's disease
Genome-wide association studies have discovered hundreds of loci associated with
complex brain disorders, but it remains unclear in which cell types these loci are active. Here …
complex brain disorders, but it remains unclear in which cell types these loci are active. Here …
Single-cell sequencing of human midbrain reveals glial activation and a Parkinson-specific neuronal state
S Smajić, CA Prada-Medina, Z Landoulsi, J Ghelfi… - Brain, 2022 - academic.oup.com
Idiopathic Parkinson's disease is characterized by a progressive loss of dopaminergic
neurons, but the exact disease aetiology remains largely unknown. To date, Parkinson's …
neurons, but the exact disease aetiology remains largely unknown. To date, Parkinson's …
Robust dysregulation of gene expression in substantia nigra and striatum in Parkinson's disease
RM Miller, GL Kiser, TM Kaysser-Kranich… - Neurobiology of …, 2006 - Elsevier
Large-scale genomics approaches are now widely utilized to study a myriad of human
diseases. These powerful techniques, when combined with data analysis tools, detect …
diseases. These powerful techniques, when combined with data analysis tools, detect …
Identification of candidate Parkinson disease genes by integrating genome-wide association study, expression, and epigenetic data sets
Importance Substantial genome-wide association study (GWAS) work in Parkinson disease
(PD) has led to the discovery of an increasing number of loci shown reliably to be associated …
(PD) has led to the discovery of an increasing number of loci shown reliably to be associated …
Single-cell epigenomic analyses implicate candidate causal variants at inherited risk loci for Alzheimer's and Parkinson's diseases
Genome-wide association studies of neurological diseases have identified thousands of
variants associated with disease phenotypes. However, most of these variants do not alter …
variants associated with disease phenotypes. However, most of these variants do not alter …
Expression profiling of substantia nigra in Parkinson disease, progressive supranuclear palsy, and frontotemporal dementia with parkinsonism
Background Parkinson disease (PD) is characterized by loss of dopaminergic neurons in the
substantia nigra. Genes contributing to rare mendelian forms of PD have been identified, but …
substantia nigra. Genes contributing to rare mendelian forms of PD have been identified, but …
[PDF][PDF] Single-cell RNA-seq of mouse dopaminergic neurons informs candidate gene selection for sporadic Parkinson disease
PW Hook, SA McClymont, GH Cannon, WD Law… - The American Journal of …, 2018 - cell.com
Genetic variation modulating risk of sporadic Parkinson disease (PD) has been primarily
explored through genome-wide association studies (GWASs). However, like many other …
explored through genome-wide association studies (GWASs). However, like many other …
[HTML][HTML] Moving beyond neurons: the role of cell type-specific gene regulation in Parkinson's disease heritability
Abstract Parkinson's disease (PD), with its characteristic loss of nigrostriatal dopaminergic
neurons and deposition of α-synuclein in neurons, is often considered a neuronal disorder …
neurons and deposition of α-synuclein in neurons, is often considered a neuronal disorder …