In this Commentary, the authors expand on their earlier studies of the solid-state long-term
isothermal crystallization of amorphous API from the glassy state in amorphous solid …

Amorphous solid dispersions stabilized by one or more polymer (s) have been widely used
for delivering amorphous drugs with poor water solubilities, and they have gained great …

Before pursuing the laborious route of amorphous solid dispersion formulation and
development, which is the topic of many of the subsequent chapters in this book, the …

In this Perspective, the authors examine the various factors that should be considered when
attempting to use miscible amorphous API–excipient mixtures (amorphous solid dispersions …

In the past decade, there has been a high level of interest and investigation on the use of
amorphous solids of small molecule active pharmaceutical ingredients (APIs)(MW j 1000 …

Amorphous drug delivery systems are increasingly utilized to enhance aqueous solubility
and oral bioavailability. However, they lack physical and/or chemical stability. One of the …

Amorphous solid dispersions (ASDs), in which polymers are admixed with a drug, retard or
inhibit crystallization of the drug, increasing the drug's apparent solubility and oral …

Historically, amorphous solid dispersion technology with polymeric carriers has been
employed to stabilize high-energy amorphous phases of poorly water-soluble drug …

Poor water solubility of many drugs has emerged as one of the major challenges in the
pharmaceutical world. Polymer-based amorphous solid dispersions have been considered …

Providing a roadmap from early to late stages of drug development, this book overviews
amorphous solid dispersion technology–a leading platform to deliver poorly water soluble …