The role of diet related short-chain fatty acids in colorectal cancer metabolism and survival: prevention and therapeutic implications

SD Gomes, CS Oliveira, J Azevedo-Silva… - Current medicinal …, 2020 - ingentaconnect.com
Colorectal Cancer (CRC) is a major cause of cancer-related death worldwide. CRC
increased risk has been associated with alterations in the intestinal microbiota, with …

Gut microbiota-derived short-chain fatty acids and colorectal cancer: Ready for clinical translation?

H Hou, D Chen, K Zhang, W Zhang, T Liu, S Wang… - Cancer Letters, 2022 - Elsevier
Colorectal cancer (CRC) is the third most common cancer and the second leading cause of
cancer-related death worldwide. It involves the complex interactions between genetic …

[HTML][HTML] Microbiota-derived short-chain fatty acids: new road in colorectal cancer therapy

S Gomes, F Baltazar, E Silva, A Preto - Pharmaceutics, 2022 - mdpi.com
The colon microbiota is an important player in colorectal cancer (CRC) development, which
is responsible for most of the cancer-related deaths worldwide. During carcinogenesis, the …

[HTML][HTML] Participation of short-chain fatty acids and their receptors in gut inflammation and colon cancer

MD Carretta, J Quiroga, R López, MA Hidalgo… - Frontiers in …, 2021 - frontiersin.org
Short-chain fatty acids (SCFAs) are the main metabolites produced by the bacterial
fermentation of dietary fiber, and they play a critical role in the maintenance of intestinal …

[HTML][HTML] Association of circulating short chain fatty acid levels with colorectal adenomas and colorectal cancer

F Genua, B Mirković, A Mullee, M Levy… - Clinical Nutrition …, 2021 - Elsevier
Background & aims Short chain fatty acid (SCFAs) are bacterially derived metabolites
suggested to have protective roles against colorectal cancer (CRC) development. However …

Short-chain free-fatty acid G protein-coupled receptors in colon cancer

NH Moniri, Q Farah - Biochemical Pharmacology, 2021 - Elsevier
The dietary role of macronutrients and their metabolites in cancer has been evident for many
decades. Dietary ingestion of fat, carbohydrates, protein, and fiber, as well as probiotics that …

[HTML][HTML] Role of microbiota-derived short-chain fatty acids in cancer development and prevention

R Mirzaei, A Afaghi, S Babakhani, MR Sohrabi… - Biomedicine & …, 2021 - Elsevier
Following cancer, cells in a particular tissue can no longer respond to the factors involved in
controlling cell survival, differentiation, proliferation, and death. In recent years, it has been …

[HTML][HTML] Short-chain fatty acid concentrations in the incidence and risk-stratification of colorectal cancer: a systematic review and meta-analysis

E Alvandi, WKM Wong, MV Joglekar, KJ Spring… - BMC medicine, 2022 - Springer
Background The beneficial role of gut microbiota and bacterial metabolites, including short-
chain fatty acids (SCFAs), is well recognized, although the available literature around their …

The role of short-chain fatty acids in intestinal barrier function, inflammation, oxidative stress, and colonic carcinogenesis

P Liu, Y Wang, G Yang, Q Zhang, L Meng, Y Xin… - Pharmacological …, 2021 - Elsevier
Short-chain fatty acids (SCFAs), mainly including acetate, propionate, and butyrate, are
metabolites produced during the bacterial fermentation of dietary fiber in the intestinal tract …

Protective effect of the “food-microorganism-SCFAs” axis on colorectal cancer: From basic research to practical application

H Shuwen, D Miao, Q Quan, W Wei… - Journal of cancer …, 2019 - Springer
Abstracts Background Recent studies have shown that the short-chain fatty acids (SCFAs)
produced by the gut microbiota play a positive role in the development of colorectal cancer …