Interleukin-11 is a therapeutic target in idiopathic pulmonary fibrosis
Idiopathic pulmonary fibrosis (IPF) is a progressive fibrotic lung disease where invasive
pulmonary myofibroblasts secrete collagen and destroy lung integrity. Here, we show that …
pulmonary myofibroblasts secrete collagen and destroy lung integrity. Here, we show that …
Targeting interleukin-13 with tralokinumab attenuates lung fibrosis and epithelial damage in a humanized SCID idiopathic pulmonary fibrosis model
LA Murray, H Zhang, SR Oak, AL Coelho… - American journal of …, 2014 - atsjournals.org
The aberrant fibrotic and repair responses in the lung are major hallmarks of idiopathic
pulmonary fibrosis (IPF). Numerous antifibrotic strategies have been used in the clinic with …
pulmonary fibrosis (IPF). Numerous antifibrotic strategies have been used in the clinic with …
[HTML][HTML] Interleukin-11 signaling underlies fibrosis, parenchymal dysfunction, and chronic inflammation of the airway
Abstract Interleukin (IL)-11 evolved as part of the innate immune response. In the human
lung, IL-11 upregulation has been associated with viral infections and a range of …
lung, IL-11 upregulation has been associated with viral infections and a range of …
Fibroblast‐specific IL11 signaling drives chronic inflammation in murine fibrotic lung disease
Repetitive pulmonary injury causes fibrosis and inflammation that underlies chronic lung
diseases such as idiopathic pulmonary fibrosis (IPF). Interleukin 11 (IL11) is important for …
diseases such as idiopathic pulmonary fibrosis (IPF). Interleukin 11 (IL11) is important for …
[HTML][HTML] Blockade of IL-6 Trans signaling attenuates pulmonary fibrosis
TTT Le, H Karmouty-Quintana, E Melicoff… - The Journal of …, 2014 - journals.aai.org
Idiopathic pulmonary fibrosis (IPF) is a lethal lung disease with progressive fibrosis and
death within 2–3 y of diagnosis. IPF incidence and prevalence rates are increasing annually …
death within 2–3 y of diagnosis. IPF incidence and prevalence rates are increasing annually …
[HTML][HTML] IL-11 system participates in pulmonary artery remodeling and hypertension in pulmonary fibrosis
J Milara, I Roger, P Montero, E Artigues, J Escrivá… - Respiratory …, 2022 - Springer
Background Pulmonary hypertension (PH) associated to idiopathic pulmonary fibrosis (IPF)
portends a poor prognosis. IL-11 has been implicated in fibrotic diseases, but their role on …
portends a poor prognosis. IL-11 has been implicated in fibrotic diseases, but their role on …
Therapeutic targeting of IL-4-and IL-13-responsive cells in pulmonary fibrosis
C Jakubzick, SL Kunkel, RK Puri, CM Hogaboam - Immunologic research, 2004 - Springer
Severe forms of idiopathic interstitial pneumonia (IIP), such as usual interstitial pneumonia
(UIP), can be impervious to modern steroid and immunosuppressive treatment regimens …
(UIP), can be impervious to modern steroid and immunosuppressive treatment regimens …
IL-25 and type 2 innate lymphoid cells induce pulmonary fibrosis
E Hams, ME Armstrong, JL Barlow… - Proceedings of the …, 2014 - National Acad Sciences
Disease conditions associated with pulmonary fibrosis are progressive and have a poor
long-term prognosis with irreversible changes in airway architecture leading to marked …
long-term prognosis with irreversible changes in airway architecture leading to marked …
[HTML][HTML] Role of IL-17 family cytokines in the progression of IPF from inflammation to fibrosis
YJ Nie, SH Wu, YH Xuan, G Yan - Military Medical Research, 2022 - Springer
Idiopathic pulmonary fibrosis (IPF) is a fatal chronic interstitial lung disease with no
established treatment and is characterized by progressive scarring of the lung tissue and an …
established treatment and is characterized by progressive scarring of the lung tissue and an …
Bleomycin and IL-1β–mediated pulmonary fibrosis is IL-17A dependent
Idiopathic pulmonary fibrosis (IPF) is a destructive inflammatory disease with limited
therapeutic options. To better understand the inflammatory responses that precede and …
therapeutic options. To better understand the inflammatory responses that precede and …