Subset# 201 is a clinically indolent subgroup of patients with chronic lymphocytic leukemia
defined by the expression of stereotyped, mutated IGHV4-34/IGLV1-44 BCR Ig. Subset# 201 …

Several studies indicate that the development of chronic lymphocytic leukemia (CLL) may be
influenced by antigen recognition through the clonotypic B-cell receptors (BCRs). However …

Purpose: We sought to investigate whether B cell receptor immunoglobulin (BcR IG)
stereotypy is associated with particular clinicobiological features among chronic lymphocytic …

The B-cell receptor (BCR) is a key survival molecule for normal B cells and for most B-cell
malignancies. Recombinatorial and mutational patterns in the clonal immunoglobulin (Ig) of …

Chronic lymphocytic leukemia (CLL) patients assigned to stereotyped subset 4 possess
distinctive patterns of intraclonal diversification (ID) within their immunoglobulin (IG) genes …

B-cell receptor (BCR) signaling is crucial for chronic lymphocytic leukemia (CLL) biology.
IGLV3-21–expressing B cells may acquire a single point mutation (R110) that triggers …

Sequence convergence, otherwise stereotypy, of B cell receptor immunoglobulin (BcR IG)
from unrelated patients is a distinctive feature of the IG gene repertoire in chronic …

Over the last decade, immunogenetic analysis of B-cell receptor immunoglobulins (BcR IGs)
has proved to be a particularly fruitful field in chronic lymphocytic leukemia (CLL), not only …

Chronic lymphocytic leukemia (CLL) major stereotyped subset 2 (IGHV3-21/IGLV3-21,∼
2.5% of all cases of CLL) is an aggressive disease variant, irrespective of the somatic …

Pivotal studies from the 1990s offered the first pieces of evidence for the role of
immunoglobulin (IG) receptors and antigen stimulation in the natural history of chronic …