Hepatitis C Virus (HCV) infection is a global public health problem affecting over 160 million
individuals worldwide. Its symptoms include chronic hepatitis, liver cirrhosis and …

Tetraspanins are integral transmembrane proteins organized in microdomains displaying
specific and direct interactions with other tetraspanins and molecular partners. Among them …

CD81, a member of the tetraspanin integral membrane protein family, has been identified as
an essential receptor for HCV (hepatitis C virus). The present review highlights recent …

Hepatitis C virus (HCV) causes chronic liver disease, cirrhosis, and primary liver cancer.
Despite 130 million people being at risk worldwide, no vaccine exists, and effective therapy …

The tetraspanin CD81 plays an essential role in diverse cellular processes. CD81 also acts
as an entry receptor for HCV through an interaction between the large extracellular loop …

Background Three percent of the world's population is chronically infected with hepatitis C
virus (HCV) and thus at risk of developing liver cancer. Although precise mechanisms …

CD81 is a tetraspanin protein that is involved in several essential cellular functions, as well
as in the hepatitis C virus (HCV) infection. CD81 interacts with a high stoichiometry with its …

The CD81 tetraspanin was first identified as a hepatitis C virus (HCV) receptor by its ability to
bind the soluble ectodomain of envelope glycoprotein E2 (sE2). More recently, it has been …

Aim Cellular CD81 is a well characterized hepatitis C virus (HCV) entry factor, while the
relevance of soluble exosomal CD81 in HCV pathogenesis is poorly defined. We performed …

Human tetraspanin CD81 is a putative receptor for hepatitis C virus (HCV), because it has
been shown to bind 'bona fide'HCV particles. CD81, as all tetraspanins, spans the …