1 The mechanisms responsible for sensing hypoxia and initiating hypoxic pulmonary
vasoconstriction (HPV) are unclear. We therefore examined the roles of the mitochondrial …

We tested whether mitochondria function as the O2 sensor underlying hypoxic pulmonary
vasoconstriction (HPV). In buffer-perfused rat lungs, rotenone, myxothiazol, and …

Hypoxic pulmonary vasoconstriction (HPV) becomes activated in response to alveolar
hypoxia and, although the characteristics of HPV have been well described, the underlying …

The effector mechanism of hypoxic pulmonary vasoconstriction (HPV) involves K+ channel
inhibition with subsequent membrane depolarization. It remains uncertain how hypoxia …

Hypoxia causes constriction in small pulmonary arteries and dilatation in systemic arteries.
Hypoxic pulmonary vasoconstriction (HPV) is an important mechanism by which pulmonary …

Despite extensive studies over many years, there is still no real consensus regarding the
mechanisms responsible for hypoxic pulmonary vasoconstriction (HPV). This is partially …

Hypoxic pulmonary vasoconstriction (HPV) matches lung perfusion to ventilation for
optimizing pulmonary gas exchange; however, the underlying mechanism has not yet been …

The precise mechanisms underlying hypoxic pulmonary vasoconstriction (HPV) are still
elusive. The recent discovery of K+ channels that are depressed by hypoxia in pulmonary …

The purpose of this study was to test whether inhibition of glycolysis would potentiate
hypoxic vasoconstriction in isolated rat lungs, and, if so, to evaluate whether potentiation …

A key event in hypoxic pulmonary vasoconstriction (HPV) is the elevation in smooth muscle
intracellular Ca2+ concentration. However, there is controversy concerning the source of this …