Introduction Progress in the knowledge of metabolic interactions between cancer and its
microenvironment is ongoing and may lead to novel therapeutic approaches. Until recently …

The Warburg effect in tumour cells is associated with the upregulation of glycolysis to
generate ATP, even under normoxic conditions and the presence of fully functioning …

Intercellular communication between cancer cells and other cells in the tumor
microenvironment plays a defining role in tumor development. Tumors contain infiltrates of …

Drastically elevated glycolytic activity is a prominent metabolic feature of cancer cells. Until
recently it was thought that tumor cells shift their entire energy production from oxidative …

We have recently proposed a new mechanism for explaining energy transfer in cancer
metabolism. In this scenario, cancer cells behave as metabolic parasites, by extracting …

Glycolysis has long been considered as the major metabolic process for energy production
and anabolic growth in cancer cells. Although such a view has been instrumental for the …

Research on mitochondrial fusion and fission (mitochondrial dynamics) has gained much
attention in recent years, as it is important for understanding many biological processes …

Mitochondrial activity is central to tissue homeostasis. Mitochondria dysfunction constitutes a
hallmark of many genetic diseases and plays a key role in tumor progression. The essential …

Cancer cells reprogram their metabolism using different strategies to meet energy and
anabolic demands to maintain growth and survival. Understanding the molecular and …

The importance of mitochondria as oxygen sensors as well as producers of ATP and
reactive oxygen species (ROS) has recently become a focal point of cancer research …