Discovery and characterization of the cytokine receptor-cytokine-decoy receptor triad formed
by receptor activator of nuclear factor kappa-B ligand (RANKL)–receptor activator of NF-κB …

Bone‐related diseases, such as osteoporosis and rheumatoid arthritis, affect hundreds of
millions of people worldwide and pose a tremendous burden to health care. By deepening …

Since the receptor activator of nuclear factor-kappa B ligand (RANKL), its cognate receptor
activator of nuclear factor-kappa B (RANK), and the decoy receptor osteoprotegerin (OPG) …

The receptor activator of nuclear factor kappa-B ligand (RANKL)-RANK-osteoprotegerin
(OPG) system is critical to bone homeostasis, but genetically deficient mouse models have …

Receptor activator of NF-κB (RANK) ligand (RANKL) induces the differentiation of monocyte/
macrophage–lineage cells into the bone–resorbing cells called osteoclasts. Because …

The past decade has seen an explosion in the field of bone biology. The area of bone
biology over this period of time has been marked by a number of key discoveries that have …

1997 saw the identification of a novel set of proteins within the tumor necrosis factor
(TNF)/TNF receptor families that are required for the control of bone remodeling. Therefore …

The identification of Receptor activator of nuclear factor kappa B ligand (RANKL) and its
cognate receptor Receptor activator of nuclear factor kappa B (RANK) during a search for …

The receptor activator of nuclear factor‑κB ligand (RANKL)/RANK/osteoprotegerin (OPG)
system was identified in the late 1990s, ending the search for the specific factors expressed …

The discovery of the RANKL/RANK/OPG system in the mid 1990s for the regulation of bone
resorption has led to major advances in our understanding of how bone modeling and …