Staphylococcus aureus is a versatile human commensal bacteria and pathogen that causes
various community and hospital-acquired infections. The S. aureus efflux pump NorA which …

Staphylococcus aureus has acquired resistance to antibiotics since their first use. The S.
aureus protein NorA, an efflux pump belonging to the major facilitator superfamily (MFS) …

Overexpression of efflux pumps is an important mechanism by which bacteria evade effects
of substrate antimicrobial agents and inhibition of such pumps is a promising strategy to …

Overexpression of efflux pumps is an important mechanism by which bacteria evade the
effects of substrate antimicrobial agents. Inhibition of such pumps is a promising strategy to …

Background: Methicillin-resistant and vancomycin-resistant Staphylococcus aureus are
pathogens causing severe infectious diseases that pose real public health threats problems …

NorA, an extensively studied efflux pump in Staphylococcus aureus, has been connected to
fluoroquinolone, antiseptic, and disinfection resistance. Several studies have also …

Antimicrobial resistance (AMR) represents a hot topic in drug discovery. Besides the
identification of new antibiotics, the use of nonantibiotic molecules to block resistance …

Objectives Evaluation of novel synthetic analogues of piperine as inhibitors of multidrug
efflux pump NorA of Staphylococcus aureus. Methods A library of piperine-derived …

Overexpression of efflux pumps is an important mechanism by which bacteria evade the
effects of antimicrobial agents that are substrates. NorA is a Staphylococcus aureus efflux …

Objective Efflux pumps are transmembrane proteins associated with bacterial resistance
mechanisms. Bacteria use these proteins to actively transport antibiotics to the extracellular …