The mode of actions of the Adacolumn therapeutic leucocytapheresis in patients with inflammatory bowel disease: a concise review

H Hanai, Y Takeda, M Eberhardson… - Clinical & …, 2011 - academic.oup.com
Patients with active inflammatory bowel disease (IBD) have elevated and activated myeloid
leucocytes which infiltrate the colonic mucosa in vast numbers. Myeloid leucocytes such as …

Therapeutic leukocytapheresis for inflammatory bowel disease

AR Saniabadi, H Hanai, K Fukunaga, K Sawada… - … and Apheresis Science, 2007 - Elsevier
The inference that granulocytes and monocytes/macrophages (GM) are part of the
immunopathogenesis of inflammatory bowel disease (IBD) and hence should be targets of …

Adacolumn for selective leukocytapheresis as a non‐pharmacological treatment for patients with disorders of the immune system: an adjunct or an alternative to drug …

AR Saniabadi, H Hanai, Y Suzuki… - Journal of Clinical …, 2005 - Wiley Online Library
Inflammatory and/or autoimmune diseases like ulcerative colitis (UC) or Crohn's disease
(CD) are debilitating chronic disorders that poorly respond to pharmacological interventions …

[HTML][HTML] Positions of selective leukocytapheresis in the medical therapy of ulcerative colitis

H Hanai - World Journal of Gastroenterology: WJG, 2006 - ncbi.nlm.nih.gov
Ulcerative colitis (UC) and Crohn's disease (CD) are the major forms of idiopathic
inflammatory bowel disease (IBD). Both UC and CD are debilitating chronic disorders that …

Granulomonocytapheresis as a cell‐dependent treatment option for patients with inflammatory bowel disease: concepts and clinical features for better therapeutic …

AR Saniabadi, T Tanaka, T Yamamoto… - Journal of clinical …, 2019 - Wiley Online Library
Ulcerative colitis (UC) and Crohn's disease (CD) are major phenotypes of the chronic
inflammatory bowel disease (IBD), which afflicts millions of individuals throughout the world …

[HTML][HTML] Treating inflammatory bowel disease by adsorptive leucocytapheresis: a desire to treat without drugs

AR Saniabadi, T Tanaka, T Ohmori… - World Journal of …, 2014 - ncbi.nlm.nih.gov
Ulcerative colitis and Crohn's disease are the major phenotypes of the idiopathic
inflammatory bowel disease (IBD), which afflicts millions of individuals throughout the world …

Adacolumn leucocytapheresis for ulcerative colitis: clinical and endoscopic features of responders and unresponders

R Sacco, T Tanaka, T Yamamoto, G Bresci… - Expert Review of …, 2015 - Taylor & Francis
Cytokines such as TNF-α have a validated role in the immunopathogensis of ulcerative
colitis (UC), and intercepting inflammatory cytokines is currently the best option for …

Targeting neutrophils in inflammatory bowel disease: revisiting the role of adsorptive granulocyte and monocyte apheresis

G Bamias, E Zampeli, E Domènech - Expert Review of …, 2022 - Taylor & Francis
Introduction Inflammatory bowel disease (IBD) is a chronic immune-mediated disease of the
gastrointestinal tract comprising Crohn's disease (CD) and ulcerative colitis (UC). While any …

Clinical and endoscopic features of responders and non-responders to adsorptive leucocytapheresis: a report based on 120 patients with active ulcerative colitis

T Tanaka, H Okanobu, Y Kuga, Y Yoshifuku… - … clinique et biologique, 2010 - Elsevier
BACKGROUND AND OBJECTIVE: Elevated/activated myeloid leucocytes, like the CD14 (+)
CD16 (+) monocytes are sources of TNF-α, and therefore, selective depletion of these cells …

Adacolumn selective leukocyte adsorption apheresis in patients with active ulcerative colitis: clinical efficacy, effects on plasma IL-8, and expression of Toll-like …

H Aoki, K Nakamura, Y Yoshimatsu, Y Tsuda… - Digestive diseases and …, 2007 - Springer
Adacolumn selective granulocyte and monocyte apheresis (GMA) depletes activated
leukocytes in patients with ulcerative colitis (UC). However, this per se cannot fully explain …