On‐tissue chemical derivatization in mass spectrometry imaging

C Harkin, KW Smith, FL Cruickshank… - Mass spectrometry …, 2022 - Wiley Online Library
Mass spectrometry imaging (MSI) combines molecular and spatial information in a valuable
tool for a wide range of applications. Matrix‐assisted laser desorption/ionization (MALDI) is …

On-tissue derivatization via electrospray deposition for matrix-assisted laser desorption/ionization mass spectrometry imaging of endogenous fatty acids in rat brain …

Q Wu, TJ Comi, B Li, SS Rubakhin… - Analytical …, 2016 - ACS Publications
Matrix-assisted laser desorption/ionization (MALDI) mass spectrometry imaging (MSI) is
used for the multiplex detection and characterization of diverse analytes over a wide mass …

Effective sample preparations in imaging mass spectrometry

S Shimma, Y Sugiura - Mass Spectrometry, 2014 - jstage.jst.go.jp
Matrix-assisted laser desorption/ionization (MALDI) imaging mass spectrometry (IMS) can
be used to visualize the distribution of biomolecules (proteins, peptides, metabolites) and …

Multimodal imaging of biological tissues using combined MALDI and NAPA-LDI mass spectrometry for enhanced molecular coverage

JA Fincher, AR Korte, S Yadavilli, NJ Morris, A Vertes - Analyst, 2020 - pubs.rsc.org
Mass spectrometry imaging (MSI) is a powerful analytical technique that enables detection,
discovery, and identification of multiple classes of biomolecules, while simultaneously …

[HTML][HTML] Imaging mass spectrometry: a perspective

RM Caprioli - Journal of Biomolecular Techniques: JBT, 2019 - ncbi.nlm.nih.gov
Imaging mass spectrometry (IMS) has emerged as an important imaging modality because
of its broad non-specific nature for molecular detection from highly complex samples. Within …

Alternative two‐step matrix application method for imaging mass spectrometry to avoid tissue shrinkage and improve ionization efficiency

S Shimma, Y Takashima, J Hashimoto… - Journal of Mass …, 2013 - Wiley Online Library
Mass spectrometry (MS) was used to measure the concentrations of drug and biological
compounds in plasma and tissues. Matrix‐assisted laser desorption/ionization (MALDI) …

Matrix solution fixation: histology-compatible tissue preparation for MALDI mass spectrometry imaging

NYR Agar, HW Yang, RS Carroll, PM Black… - Analytical …, 2007 - ACS Publications
Mass spectrometry imaging (MSI) acquires a grid of spatially resolved mass spectra and
provides a molecular landscape of a tissue. This can have a myriad of uses: from basic …

Enhanced on-tissue chemical derivatization with hydrogel assistance for mass spectrometry imaging

Q Zang, M Wang, Y Zhu, L Wang, Z Luo, X Li… - Analytical …, 2021 - ACS Publications
The improvement of on-tissue chemical derivatization for mass spectrometry imaging (MSI)
of low-abundance and/or poorly ionizable functional molecules in biological tissue without …

Recent advancements in matrix-assisted laser desorption/ionization mass spectrometry imaging

TC Baker, J Han, CH Borchers - Current opinion in biotechnology, 2017 - Elsevier
Highlights•New MALDI matrices and new matrix deposition techniques have advanced MS
imaging.•Multiplexed MALDI-MSI can image hundreds to more than 1000 molecular …

Infrared matrix-assisted laser desorption electrospray ionization (IR-MALDESI) imaging source coupled to a FT-ICR mass spectrometer

G Robichaud, JA Barry, KP Garrard… - Journal of the …, 2012 - ACS Publications
Mass spectrometry imaging (MSI) allows for the direct monitoring of the abundance and
spatial distribution of chemical compounds over the surface of a tissue sample. This …