Many encapsulated bacteria use capsules to cause invasive diseases. However, it remains
largely unknown how the capsules enhance bacterial virulence under in vivo infection …

Polysaccharide capsule is the main virulence factor of K. pneumoniae, a major pathogen of
bloodstream infections in humans. While more than 80 capsular serotypes have been …

In environments characterized by extended multi-stress conditions, pathogens develop a
variety of immune escape mechanisms to enhance their ability to infect the host. The …

The polysaccharide capsule that surrounds Streptococcus pneumoniae (Spn) is one of its
most important virulence determinants, serving to protect against phagocytosis. To date, 100 …

Extracellular capsule polysaccharides increase the cellular fitness under abiotic stresses
and during competition with other bacteria. They are best‐known for their role in virulence …

The increasing prevalence of antibiotic-resistant bacteria portends an impending
postantibiotic age, characterized by diminishing efficacy of common antibiotics and routine …

The liver is positioned at the interface between two routes traversed by pathogens in
disseminating infection. Whereas blood-borne pathogens are efficiently cleared in hepatic …

Klebsiella pneumoniae successfully colonizes host tissues by recognizing and interacting
with cholesterol present on membrane-associated lipid rafts. In this study, we evaluated the …

Extracellular capsules constitute the outermost layer of many bacteria, are major virulence
factors, and affect antimicrobial therapies. They have been used as epidemiological markers …

Vaccination has substantially reduced the morbidity and mortality of bacterial diseases, but
mechanisms of vaccine-elicited pathogen clearance remain largely undefined. We report …