Hepatocellular carcinoma (HCC) is a leading cause of cancer deaths worldwide, and an
association between altered bile acid (BA) metabolism, down‐regulation of farnesoid X …

Farnesoid X receptor (FXR) belongs to the nuclear receptor superfamily with its endogenous
ligands bile acids. Mice with whole body FXR deficiency develop liver tumors …

The farnesoid X receptor (FXR) controls the synthesis and transport of bile acids (BAs). Mice
lacking expression of FXR, designated Fxr-null, have elevated levels of serum and hepatic …

Farnesoid X receptor (FXR) is the master regulator of bile acid (BA) homeostasis because it
controls BA synthesis, influx, efflux, and detoxification in the gut/liver axis. Deregulation of …

Abstract Farnesoid X receptor (FXR, NR1H4) is a member of the nuclear hormone receptor
superfamily, which plays an essential role in regulating bile acid, lipid, and glucose …

Spontaneous development of liver tumors in the absence of the bile acid receptor farnesoid
X receptor. Yang F, Huang X, Yi T, Yen Y, Moore DD, Huang W. Farnesoid X receptor (FXR …

Farnesoid X receptor (FXR) is a ligand-activated transcription factor involved in the control of
bile acid (BA) synthesis and enterohepatic circulation. FXR can influence glucose and lipid …

Increased dietary fat consumption is associated with colon cancer development. The exact
mechanism by which fat induces colon cancer is not clear, however, increased bile acid …

Farnesoid X receptor (FXR)(nuclear receptor subfamily 1, group H, member 4) is a member
of nuclear hormone receptor superfamily, which plays essential roles in metabolism of bile …

Farnesoid X receptor (FXR), the primary bile acid-sensing nuclear receptor, also is known
for its anticancer properties. It is known that FXR deficiency in mice results in spontaneous …