The liver receives blood from both the systemic circulation and the intestine, and in
distinctive, thin-walled sinusoids this mixture passes over a large macrophage population …

The liver is a unique anatomical and immunological site in which antigen‐rich blood from
the gastrointestinal tract is pressed through a network of sinusoids and scanned by antigen …

Because of its location and function, the liver is continuously exposed to a large antigenic
load that includes pathogens, toxins, tumor cells and harmless dietary antigens. The range …

From the immunology standpoint, the liver is a peculiar organ for several reasons that range
from its anatomical location to its cytoarchitecture and its variety of specific functions …

The critical metabolic functions of the liver often eclipse any perception of its role as an
immune organ. However, the liver as a mediator of systemic and local innate immunity and …

The immunologic properties of the liver confront one with a combination of unique
phenomena. These include graft survival across major histocompatibility antigen disparities …

The liver is a key, frontline immune tissue. Ideally positioned to detect pathogens entering
the body via the gut, the liver appears designed to detect, capture, and clear bacteria …

The liver regulates T-cell homeostasis, induces T-cell tolerance, and supports intrahepatic T-
cell responses against hepatotropic pathogens. Many data from clinical and preclinical …

Immunologic injury in the liver involves immigrant T and B lymphocytes and a resident
lymphoid population that comprises distinct lymphocytic cells and accessory cells. The …

The liver is the largest organ in the body and is generally regarded by non-immunologists as
not having lymphoid function. However, such is far from accurate. This review highlights the …