A multicellular ventricular fiber model was used to determine mechanisms of slowed
conduction and conduction failure during acute ischemia. We simulated the three major …

Objective: To study the ionic mechanisms of electrophysiologic changes in cell excitability
and action potential duration during the acute phase of myocardial ischemia. Methods …

Myocardial ischemia is one of the main causes of sudden cardiac death, with 80% of victims
suffering from coronary heart disease. In acute myocardial ischemia, the obstruction of …

The mechanisms underlying Ca2+/calmodulin-dependent protein kinase II (CaMKII)-
induced arrhythmias in ischemia-reperfusion (I/R) are not fully understood. We tested the …

Rationale: Although ventricular premature beats (VPBs) during acute regional ischemia
have been linked to mechanical stretch of ischemic tissue, whether and how ischemia …

The goal of this modeling research is to provide mechanistic insight into the effect of altered
membrane kinetics associated with 5–12 min of acute global ischemia on the upper limit of …

Abstract Objective: The objectives were (1) to develop a cellular model of simulated
ischaemia and reperfusion in isolated ventricular myocytes;(2) to determine effects of …

Heterogeneity of myocardial structure and membrane excitability is accentuated by
pathology and remodeling. In this study, a detailed model of the ventricular myocyte in a …

In this study, we have used computer simulations to study the mechanisms of extracellular
K+ accumulation during acute ischemia. A modified version of the Luo-Rudy phase II action …

Little is known about the mechanisms of vulnerability and defibrillation under ischemic
conditions. We investigated these mechanisms in 18 Langendorff-perfused rabbit hearts …