Chronic cadmium exposure at environmental-relevant level accelerates the development of hepatotoxicity to hepatocarcinogenesis

Y Xu, W Mu, J Li, Q Ba, H Wang - Science of the Total Environment, 2021 - Elsevier
Cadmium (Cd) is an environmental heavy metal with long biological half-time and adverse
health effects. The long-term toxicity of Cd at low levels remains to be elucidated. Here, we …

Low-dose cadmium causes metabolic and genetic dysregulation associated with fatty liver disease in mice

YM Go, RL Sutliff, JD Chandler, R Khalidur… - Toxicological …, 2015 - academic.oup.com
Cadmium (Cd) is present in food at low levels and accumulates in humans throughout life
because it is not effectively excreted. Cd from smoking or occupational exposure shows …

Dual role of cadmium in rat liver: Inducing liver injury and inhibiting the progression of early liver cancer

H Zhang, J Yan, Y Xie, X Chang, J Li, C Ren, J Zhu… - Toxicology Letters, 2022 - Elsevier
The heavy metal cadmium (Cd) can induce damage in liver and liver cancer cells; however,
the mechanism underlying its toxicity needs to be further verified in vivo. We daily …

Cadmium modulates steatosis, fibrosis, and oncogenic signaling in liver cancer cells by activating notch and AKT/mTOR pathways

S Niture, S Gadi, M Lin, Q Qi, SS Niture… - Environmental …, 2023 - Wiley Online Library
Cadmium (Cd) is an environmental pollutant that increases hepatotoxicity and the risk of
liver diseases. In the current study, we investigated the effect of a physiologically relevant …

Subchronic exposure of mice to cadmium perturbs their hepatic energy metabolism and gut microbiome

S Zhang, Y Jin, Z Zeng, Z Liu, Z Fu - Chemical research in …, 2015 - ACS Publications
Cadmium (Cd) is an environmental pollutant known to cause liver damage; however, the
mechanisms of its hepatotoxicity remain poorly understood. In this study, the effects of …

Long-term exposure to cadmium in food and cigarette smoke, liver effects and hepatocellular carcinoma

S Satarug - Current Drug Metabolism, 2012 - ingentaconnect.com
Rising incidence of hepatocellular carcinoma (HCC) has been noted in recent years along
with diabetes for which reasons and mechanisms are unclear. The rise in HCC is attributed …

The dysbiosis of gut microbiota caused by low-dose cadmium aggravate the injury of mice liver through increasing intestinal permeability

Y Liu, Y Li, Y Xia, K Liu, L Ren, Y Ji - Microorganisms, 2020 - mdpi.com
Cadmium (Cd), widely present in food and drinking water at low doses, can cause health
risks. However, the mechanistic effects of long-term Cd exposure at low dose through dietary …

Inhibition of mitochondrial fatty acid oxidation contributes to development of nonalcoholic fatty liver disease induced by environmental cadmium exposure

X He, J Gao, H Hou, Z Qi, H Chen… - Environmental science & …, 2019 - ACS Publications
Cadmium (Cd) is one of the most prevalent toxic metal pollutants widely distributed in water
and soil environments. Epidemiological studies have shown that exposure to Cd is …

[HTML][HTML] Saturated fatty acids synergizes cadmium to induce macrophages M1 polarization and hepatic inflammation

Y Zhu, XX Chai, Y Zhao, Q Feng, R Dong… - Ecotoxicology and …, 2023 - Elsevier
Exposure to the toxic metal cadmium (Cd) is a well-established risk factor for hepatic
inflammation, but it remains unclear how metabolic components, such as different fatty acids …

Chronic cadmium exposure induced hepatic cellular stress and inflammation in aged female mice

J Zhang, Y Wang, L Fu, B Wang, YL Ji… - Journal of Applied …, 2019 - Wiley Online Library
Previous studies have revealed that acute cadmium (Cd) exposure led to inflammation in
different organs through an oxidative stress mechanism. However, whether chronic Cd …