Objectives The aim of this study was to analyse the interplay among plasmid-mediated qnr
genes, alone or in combination with multiple chromosomal-mediated fluoroquinolone (FQ) …

Objectives The aim of the study was to determine the interplay between the plasmid-
mediated qepA2 gene and multiple chromosomally mediated fluoroquinolone resistance …

This article provides an analysis of the in vitro effect of qnrA1, qnrB1, and qnrS1 genes,
combined with quinolone-resistant Ser83Leu substitutions in GyrA and/or Ser80Arg in ParC …

Objectives: To investigate the impact of plasmid-borne oqxAB genes on the development of
fluoroquinolone resistance, mutations and bacterial fitness in Escherichia coli. Methods …

Fluoroquinolones are antibacterial drugs that inhibit DNA Gyrase and Topoisomerase IV.
These essential enzymes facilitate chromosome replication and RNA transcription by …

Objectives aac (6′)-Ib-cr is the most prevalent plasmid-mediated fluoroquinolone (FQ)
resistance mechanism in Enterobacteriaceae. We aimed to analyse the interplay between …

Background Ciprofloxacin, a fluoroquinolone, targets two essential bacterial enzymes, DNA
gyrase and topoisomerase IV. Plasmid-borne qnr genes, encoding proteins that protect DNA …

Aims: To assess the different phenotypes and mechanisms of fluoroquinolone (FQ)
resistance in clinical and environmental isolates of Escherichia coli. Methods and Results …

Fluoroquinolone resistance can cause major clinical problems. Here, we investigated
fluoroquinolone resistance mechanisms in a clinical Escherichia coli isolate, HUE1, which …

Fluoroquinolone MICs are increased through the acquisition of chromosomal mutations in
the genes encoding gyrase (gyrA and gyrB) and topoisomerase IV (parC and parE) …