This paper reviews the evidence that congestive heart failure is characterized by an
increase in sympathetic nerve activity and that this may begin in an early symptomatic phase …

Congestive heart failure (CHF) is characterized not only by profound abnormalities in the
haemodynamic profile but also by changes in sympathetic cardiovascular function. These …

A review of recent randomized clinical trials has shown that neurohormonal activation starts
early in the natural history of left ventricular dysfunction and levels of the circulating …

Recent demonstration that the level of sympathetic nervous drive to the failing heart in
patients with severe heart failure is a major determinant of prognosis, and that mortality in …

Proposed reflex mechanisms for generalized neurohumoral activation in heart failure
include decreased input from inhibitory baroreceptor afferent vessels and increased input …

Congestive heart failure is usually accompanied by cardiovascular signs of an increased
sympathetic and a decreased parasympathetic efferent activity. A current hypothesis for …

OBJECTIVES.: In view of previous experimental evidence relating sympathetic nervous
overactivity in the heart to myocardial necrosis and ventricular arrhythmias, we prospectively …

Heart failure is accompanied by sympathetic overactivity, which contributes to the
pathophysiology and to poor prognosis. This paper reviews the mechanisms and potential …

The sympathetic nervous system overdrive occurring in heart failure has been reported for
more than half a century. Refinements in the methodological approaches to assess human …

One of the hallmarks of chronic congestive heart failure is an increase in sympathetic tone to
the peripheral circulation and to the heart. A correlation between plasma norepinephrine …