Objectives To compare the time to treatment failure, remission and first seizure of 12 AEDs
(carbamazepine, phenytoin, sodium valproate, phenobarbitone, oxcarbazepine, lamotrigine …

The purpose of this report was to update the 2006 International League Against Epilepsy
(ILAE) report and identify the level of evidence for long‐term efficacy or effectiveness for …

Background The choice of antiepileptic drug for an individual should be based upon the
highest quality evidence regarding potential benefits and harms of the available treatments …

Second and third generation AEDs have been directly compared to controlled‐release
carbamazepine (CBZ‐CR) as initial monotherapy for new‐onset focal epilepsy. Conversely …

Although adjunctive treatment with modern antiepileptic drugs (AEDs) is standard care in
refractory epilepsy, it is unclear how much of the effect can be attributed directly to the AEDs …

Purpose: To assess which antiepileptic medications (AEDs) have the best evidence for long‐
term efficacy or effectiveness as initial monotherapy for patients with newly diagnosed or …

Background The choice of an antiepileptic drug (AED) for any individual should take into
account reliable information about seizure control, adverse effects and cost. Carbamazepine …

Objective To update the 2004 American Academy of Neurology (AAN) guideline for treating
new-onset focal or generalized epilepsy with second-and third-generation antiepileptic …

Background Carbamazepine and valproate are drugs of first choice for epilepsy. Despite the
lack of hard evidence from individual randomized controlled trials, there is strong clinical …

Purpose: Evaluate the clinical comparability of new antiepileptic drugs (AEDs) in partial
refractory epilepsy. Methods: Systematic review of randomized trials (RCTs) comparing a …