Importance Dysregulation of corticostriatal circuitry has long been thought to be critical in the
etiology of psychotic disorders, although the differential roles played by dorsal and ventral …

Recent functional imaging work in individuals experiencing an at-risk mental state (ARMS)
for psychosis has implicated dorsal striatal abnormalities in the emergence of psychotic …

Background Psychotic symptoms are proposed to lie on a continuum, ranging from isolated
psychosis-like experiences (PLEs) in nonclinical populations to frank disorder. Here, we …

Importance Despite the well-established role of striatal dopamine in psychosis, current views
generally agree that cortical dysfunction is likely necessary for the emergence of psychotic …

Importance Previous evidence has implicated corticostriatal abnormalities in the
pathophysiology of psychosis. Although the striatum is the primary target of all efficacious …

Dysfunction of fronto-striato-thalamic (FST) circuits is thought to contribute to dopaminergic
dysfunction and symptom onset in psychosis, but it remains unclear whether this dysfunction …

Importance Severe neuropsychiatric conditions, such as schizophrenia, affect distributed
neural computations. One candidate system profoundly altered in chronic schizophrenia …

Background The striatum is abnormal in schizophrenia and possibly represents a common
neurobiological mechanism underlying psychotic disorders. Resting-state functional …

Importance Psychotic disorders (including schizophrenia, schizoaffective disorder, and
psychotic bipolar disorder) are devastating illnesses characterized by breakdown in the …

Importance Brain imaging studies have identified robust changes in brain structure and
function during the development of psychosis, but the contribution of abnormal brain …