Biliary tract carcinomas (BTCs) are among the most aggressive malignancies and have a
poor prognosis. Here, we successfully established organoid lines derived from intrahepatic …

Cholangiocarcinoma (CC) is an aggressive malignancy with an inferior prognosis due to
limited systemic treatment options. As preclinical models such as CC cell lines are extremely …

Background Gallbladder carcinoma (GBC) is a relatively rare but highly aggressive cancer
with late clinical detection and a poor prognosis. However, the lack of models with features …

Simple Summary Colorectal cancer is one of the most frequent and lethal types of cancer.
Despite advances in recent decades, our knowledge of this disease is still limited, and novel …

Cancer organoids, a three‐dimensional (3D) culture system of cancer cells derived from
tumor tissues, recapitulate physiological structure of the parental tumor. Different tumor …

Background & Aims Our goal was to develop an initial study for the proof of concept whereby
gastric cancer organoids are used as an approach to predict the tumor response in …

Patient-derived pancreatic ductal adenocarcinoma (PDAC) organoid systems show great
promise for understanding the biological underpinnings of disease and advancing …

Cancer has remained one of the biggest challenges for human health during the past few
decades despite major advances in medicine [1]. Poor prognosis of cancer is mainly caused …

Organoid cultures have emerged as powerful model systems accelerating discoveries in
cellular and cancer biology. These three-dimensional cultures are amenable to diverse …

Organoids are in vitro self-assembling, organ-like, three-dimensional cellular structures that
stably retain key characteristics of the respective organs. Organoids can be generated from …