Hypothalamic AgRP and POMC neurons are conventionally viewed as the yin and yang of
the body's energy status, since they act in an opposite manner to modulate appetite and …

In the wake of the obesity pandemic, increased research efforts are under way to define how
peripheral hormones and metabolites regulate energy homeostasis. The melanocortin …

Abstract Pro-opiomelanocortin (POMC)-expressing neurons in the arcuate nucleus of the
hypothalamus represent key regulators of metabolic homeostasis. Electrophysiological and …

Objective Obesity is one of the primary healthcare challenges of the 21st century. Signals
relaying information regarding energy needs are integrated within the brain to influence …

The current obesity epidemic faces a lack of mechanistic insights. It is known that the acute
activity changes of a growing number of brain neurons rapidly alter feeding behaviour; …

Agouti-related-peptide (AgRP) neurons—interoceptive neurons in the arcuate nucleus of the
hypothalamus (ARC)—are both necessary and sufficient for driving feeding behavior. To …

The central nervous system (CNS) controls food intake and energy expenditure via tight
coordinations between multiple neuronal populations. Specifically, two distinct neuronal …

Hypothalamic neurons respond to nutritional cues by altering gene expression and neuronal
excitability. The mechanisms that control such adaptive processes remain unclear. Here we …

Central proopiomelanocortin (POMC) neurons form a potent anorexigenic network, but our
understanding of the integration of this hypothalamic circuit throughout the central nervous …

Molecular and cellular processes in neurons are critical for sensing and responding to
energy deficit states, such as during weight-loss. Agouti related protein (AGRP)-expressing …