Background and Purpose Efficacy of current antimalarial treatments is declining as a result
of increasing antimalarial drug resistance, so new and potent antimalarial drugs are urgently …

Novel classes of antimalarial drugs are needed due to emerging drug resistance.
Azithromycin, the first macrolide investigated for malaria treatment and prophylaxis, failed as …

Malaria remains one of the most widespread human infectious diseases, and its eradication
will largely depend on antimalarial drug discovery. Here, we present a novel approach to the …

Malaria remains the most prevalent tropical disease, and due to the spread of resistant
parasites novel therapeutics are urgently needed. Azithromycin has shown potential in …

Azithromycin, a first member of the azalide family of macrolides, while having substantial
antimalarial activity, failed as a single agent for malaria prophylaxis. In this paper we present …

Introduction The spread of artemisinin resistant Plasmodium falciparum parasites is of global
concern and highlights the need to identify new antimalarials for future treatments …

Background Resistance to front-line antimalarials (artemisinin combination therapies) is
spreading, and development of new drug treatment strategies to rapidly kill Plasmodium …

Despite the recent reductions in the global burden of malaria, this disease remains a
devastating cause of death in tropical and subtropical regions. As there is no broadly …

A series of 15-membered azalide urea and thiourea derivatives has been synthesized and
evaluated for their in vitro antimalarial activity against chloroquine-sensitive (D6) …

Whole-cell high-throughput screening of the AstraZeneca compound library against the
asexual blood stage of Plasmodium falciparum (Pf) led to the identification of amino …