Neural activity is intimately tied to blood flow in the brain. This coupling is specific enough in
space and time that modern imaging methods use local hemodynamics as a measure of …

The brain is a heterogeneous organ with regionally varied and constantly changing
energetic needs. Blood vessels in the brain are equipped with control mechanisms that …

Astrocytes are increasingly believed to play an important role in neurovascular coupling.
Recent in vivo studies have shown that intracellular calcium levels in astrocytes correlate …

According to the current model of neurovascular coupling, blood flow is controlled regionally
through phasic changes in the activity of neurons and astrocytes that signal to alter arteriole …

The tight spatial and temporal coupling between neuronal activity and blood flow ensures
that active brain regions receive an adequate supply of oxygen and energetic metabolites …

Local increase in blood flow during neural activity forms the basis for functional brain
imaging, but its mechanism remains poorly defined. Here we show that cortical astrocytes in …

In this article, we will review molecular, anatomical, physiological and pharmacological data
in an attempt to better understand how excitatory and inhibitory neurons recruited by distinct …

Astrocytes send processes to synapses and blood vessels, communicate with other
astrocytes through gap junctions and by release of ATP, and thus are an integral component …

Neurovascular coupling is a crucial mechanism that matches the high energy demand of the
brain with a supply of energy substrates from the blood. Signaling within the neurovascular …

The brain possesses two intricate mechanisms that fulfill its continuous metabolic needs:
cerebral autoregulation, which ensures constant cerebral blood flow over a wide range of …