An efficient B cell immunity requires a dynamic equilibrium between positive and negative
signals. In germinal centers (GCs), T follicular helper cells are supposed to be the positive …

T follicular regulatory cells, or Tfr cells, are a discernable population of regulatory T (Treg)
cells that migrate to the B cell follicle and germinal center (GC) upon immune challenge …

Highlights•Tfr cells regulate humoral immunity, thereby controlling antibody
responses.•Roles of Tfr cells have been unclear due to lack of specific tools to study …

High affinity antibodies result from interactions between B cells and T follicular helper (Tfh)
cells in germinal centers (GCs). Recent studies have identified an effector subset of T …

Pathogen exposure elicits production of high‐affinity antibodies stimulated by T follicular
helper (Tfh) cells in the germinal center reaction. Tfh cells provide both costimulation and …

Maturation of B cells in Germinal Centers (GC) is a hallmark in adaptive immunity and the
basis of successful vaccines that protect us against lethal infections. Nonetheless …

Follicular regulatory T cells (Tfr) are a unique subset of CD4 T cells that control and impact
adaptive immune responses in the lymphoid follicles and germinal centers (GC). Since their …

B-cell follicle represents a functionally dynamic microstructure within second lymphoid
tissues, predominantly consisting of B cells, follicular T cells and DCs. Through intimate …

The cellular networks that regulate humoral immune responses have been a focus of
research over the past three decades. Studies have shown that inhibition of immune …

The formation of high-affinity antibodies that protect against infection requires the formation
of germinal centres (GCs), where specialized T follicular helper cells (Tfh) provide help to B …