Whole-genome characterization of large-cell lung carcinoma: A comparative analysis based on the histological classification

X Wu, J Yin, Y Deng, Y Zu - Frontiers in Genetics, 2023 - frontiersin.org
Background: According to the 2015 World Health Organization classification, large cell
neuroendocrine carcinoma (LCNEC) was isolated from Large-cell lung cancer (LCLC) …

MA11. 01 Molecular Profiling of Large Cell Neuroendocrine Carcinoma Using Capture-Based Targeted Sequencing

Z Zhou, L Zhu, S Lu, J Zhang - Journal of Thoracic Oncology, 2017 - jto.org
Background Conventionally, the classification of lung cancer and many other malignancies
is determined by the histology of a tumor. Large cell neuroendocrine carcinoma (LCNEC) is …

Common and distinct features of potentially predictive biomarkers in small cell lung carcinoma and large cell neuroendocrine carcinoma of the lung by systematic and …

S Dong, J Liang, W Zhai, Z Yu - Molecular Genetics & Genomic …, 2020 - Wiley Online Library
Background Large‐cell neuroendocrine carcinoma of the lung (LCNEC) and small‐cell lung
carcinoma (SCLC) are neuroendocrine neoplasms. However, the underlying mechanisms of …

[HTML][HTML] Real-World comprehensive genomic profiling data for diagnostic clarity in pulmonary Large-Cell neuroendocrine carcinoma

L Burns, H Tukachinsky, K Raskina, RSP Huang… - Lung Cancer, 2024 - Elsevier
Background Pulmonary large-cell neuroendocrine carcinoma (LCNEC) is an uncommon
subtype of lung cancer believed to represent a spectrum of tumors sharing characteristics of …

An integrated inspection of the somatic mutations in a lung squamous cell carcinoma using next-generation sequencing

LF Stead, P Egan, A Devery, C Conway, C Daly… - PLoS …, 2013 - journals.plos.org
Squamous cell carcinoma (SCC) of the lung kills over 350,000 people annually worldwide,
and is the main lung cancer histotype with no targeted treatments. High-coverage whole …

Preferential expression of potential markers for cancer stem cells in large cell neuroendocrine carcinoma of the lung. An FFPE proteomic study

M Nomura, T Fukuda, K Fujii, T Kawamura… - Journal of Clinical …, 2011 - Springer
Background Large cell neuroendocrine carcinoma (LCNEC) of the lung, a subtype of large
cell carcinoma (LCC), is characterized by neuroendocrine differentiation that small cell lung …

P2. 15-008 Genomic Analysis to Assess a Molecular Signature in Japanese Patients with Pulmonary High Grade Neuroendocrine Carcinoma

H Kojima, M Serizawa, S Takahashi, M Isaka… - Journal of Thoracic …, 2017 - jto.org
Background Pulmonary neuroendocrine carcinoma, including small cell lung cancer
(SCLC), large cell neuroendocrine carcinoma (LCNEC), and carcinoid tumor, is a highly …

Exploring the molecular features and genetic prognostic factors of pulmonary high-grade neuroendocrine carcinomas

H Wang, L Yan, Y Zhu, W Sun, X Yang, X Liu, K Chi… - Human Pathology, 2023 - Elsevier
Molecular research on large-cell neuroendocrine carcinoma (LCNEC) and small-cell lung
cancer (SCLC) has progressed significantly. However, there are still fewer molecular …

Comparison of genomic landscapes of large cell neuroendocrine carcinoma, small cell lung carcinoma, and large cell carcinoma

Z Zhou, L Zhu, X Niu, S Shen, Y Zhao, J Zhang… - Thoracic …, 2019 - Wiley Online Library
Background The classification of large cell neuroendocrine carcinoma (LCNEC) has
generated considerable debate and has been revised since its recognition as a separate …

Genomic profiling of large-cell neuroendocrine carcinoma of the lung

T Miyoshi, S Umemura, Y Matsumura, S Mimaki… - Clinical Cancer …, 2017 - AACR
Purpose: Although large-cell neuroendocrine carcinoma (LCNEC) of the lung shares many
clinical characteristics with small-cell lung cancer (SCLC), little is known about its molecular …