Antisense oligonucleotides (ASOs) that trigger RNase-H-mediated cleavage are commonly
used to knock down transcripts for experimental or therapeutic purposes. In particular, ASOs …

An attractive approach to reduce gene expression is via the use of antisense
oligonucleotides (ASOs) that harness the RNase H1 mechanism. Here we show that RNase …

Antisense oligonucleotides (ASOs) are synthetic oligonucleotides that alter expression of
disease-associated transcripts via Watson–Crick hybridization. ASOs that function through …

RNase H1-dependent antisense oligonucleotides (ASOs) are active in reducing levels of
both cytoplasmic mRNAs and nuclear retained RNAs. Although ASO activity in the nucleus …

A variety of diseases are caused by deficiencies in amounts or activity of key proteins. An
approach that increases the amount of a specific protein might be of therapeutic benefit. We …

Before a messenger RNA (mRNA) is translated into a protein in the cytoplasm, its pre-mRNA
precursor is extensively processed through capping, splicing and polyadenylation in the …

The existence of naturally occurring antisense RNAs has been illustrated, in eukaryotes, by
an increasing number of reports. The following review presents the major findings in this …

Increasing the levels of therapeutic proteins in vivo remains challenging. Antisense
oligonucleotides (ASOs) are often used to downregulate gene expression 1 or to modify …

Mammalian genomes encode numerous natural antisense transcripts, but the function of
these transcripts is not well understood. Functional validation studies indicate that antisense …

Widespread antisense long noncoding RNA (lncRNA) overlap with many protein-coding
genes in mammals and emanate from gene promoter, enhancer, and termination regions …