The ESTRO Breur Lecture 2009. From population to voxel-based radiotherapy: exploiting intra-tumour and intra-organ heterogeneity for advanced treatment of non …

P Lambin, SF Petit, HJWL Aerts, WJC van Elmpt… - Radiotherapy and …, 2010 - Elsevier
Evidence is accumulating that radiotherapy of non-small cell lung cancer patients can be
optimized by escalating the tumour dose until the normal tissue tolerances are met. To …

Use of dose-volume histograms and biophysical models to compare 2D and 3D irradiation techniques for non-small cell lung cancer.

G Ragazzi, GM Cattaneo, C Fiorino… - The British journal of …, 1999 - academic.oup.com
For non-small cell lung cancer (NSCLC), unsatisfactory local control (LC) still remains an
important cause of failure. It has been suggested that improved LC can be achieved with …

Potential for reduced toxicity and dose escalation in the treatment of inoperable non–small-cell lung cancer: A comparison of intensity-modulated radiation therapy …

IS Grills, D Yan, AA Martinez, FA Vicini… - International Journal of …, 2003 - Elsevier
PURPOSE: To systematically evaluate four different techniques of radiation therapy (RT)
used to treat non–small-cell lung cancer and to determine their efficacy in meeting multiple …

Clinical introduction of Monte Carlo treatment planning: a different prescription dose for non-small cell lung cancer according to tumor location and size

MS Hoogeman, S van de Water, PC Levendag… - Radiotherapy and …, 2010 - Elsevier
PURPOSE: To provide a prescription dose for Monte Carlo (MC) treatment planning in
patients with non-small-cell lung cancer according to tumor size and location. METHODS …

Treatment planning for lung cancer: Traditional homogeneous point–dose prescription compared with heterogeneity-corrected dose–volume prescription

SJ Frank, KM Forster, CW Stevens, JD Cox… - International Journal of …, 2003 - Elsevier
PURPOSE: To quantify the differences in doses to target volumes and critical thoracic
structures calculated by traditional homogeneous point–dose prescription and heterogeneity …

Adaptive radiotherapy for locally advanced non-small cell lung cancer: dosimetric gain and treatment outcome prediction

P Berkovic, L Paelinck, A Gulyban… - Acta …, 2017 - Taylor & Francis
Lung cancer remains the most common and deadly cancer worldwide [1]. Non-small cell
lung cancer (NSCLC) accounts for about 85% of lung cancers, where locally advanced (LA) …

Impact of target volume segmentation accuracy and variability on treatment planning for 4D-CT-based non-small cell lung cancer radiotherapy

S Martin, C Johnson, M Brophy, DA Palma… - Acta …, 2015 - Taylor & Francis
Background. Accurate target volume segmentation is crucial for success in image-guided
radiotherapy. However, variability in anatomical segmentation is one of the most significant …

ESTRO ACROP guidelines for target volume definition in the treatment of locally advanced non-small cell lung cancer

U Nestle, D De Ruysscher, U Ricardi, X Geets… - Radiotherapy and …, 2018 - Elsevier
Radiotherapy (RT) plays a major role in the curative treatment of locally advanced non-small
cell lung cancer (NSCLC). Therefore, the ACROP committee was asked by the ESTRO to …

The potential for dose escalation in lung cancer as a result of systematically reducing margins used to generate planning target volume

C Nelson, G Starkschall, JY Chang - International Journal of Radiation …, 2006 - Elsevier
Purpose: To determine how much the radiation dose to lung tumors could be increased as
the margins used to generate planning target volume (PTV) are reduced. Methods and …

The impact of microscopic disease on the tumor control probability in non-small-cell lung cancer

C Siedschlag, L Boersma, J van Loon, M Rossi… - Radiotherapy and …, 2011 - Elsevier
PURPOSE: To indicate which clinical target volume (CTV) margin (if any) is needed for an
adequate treatment of non-small-cell lung cancer (NSCLC) using either 3D conformal or …