The mechanism of secretion and metabolism of gut-derived 5-hydroxytryptamine

N Liu, S Sun, P Wang, Y Sun, Q Hu… - International journal of …, 2021 - mdpi.com
Serotonin, also known as 5-hydroxytryptamine (5-HT), is a metabolite of tryptophan and is
reported to modulate the development and neurogenesis of the enteric nervous system, gut …

Serotonin in the gut: Blessing or a curse

S Banskota, JE Ghia, WI Khan - Biochimie, 2019 - Elsevier
Abstract Serotonin (5-hydroxytryptamine or 5-HT) once most extensively studied as a
neurotransmitter of the central nervous system, is seen to be predominantly secreted in the …

The multifaceted role of serotonin in intestinal homeostasis

N Koopman, D Katsavelis, AS Ten Hove, S Brul… - International journal of …, 2021 - mdpi.com
The monoamine serotonin, 5-hydroxytryptamine (5-HT), is a remarkable molecule with
conserved production in prokaryotes and eukaryotes and a wide range of functions. In the …

The ever-changing roles of serotonin

LA Jones, EW Sun, AM Martin, DJ Keating - The international journal of …, 2020 - Elsevier
Abstract Serotonin (5-HT) has traditional roles as a key neurotransmitter in the central
nervous system and as a regulatory hormone controlling a broad range of physiological …

The role of serotonin neurotransmission in gastrointestinal tract and pharmacotherapy

T Guzel, D Mirowska-Guzel - Molecules, 2022 - mdpi.com
5-Hydroxytryptamine (5-HT, serotonin) is a neurotransmitter in both the central nervous
system and peripheral structures, acting also as a hormone in platelets. Although its …

5-hydroxytryptamine and the gastrointestinal tract: where next?

GJ Sanger - Trends in pharmacological sciences, 2008 - cell.com
Researching the functions of serotonin, or 5-hydroxytryptamine (5-HT), in the gut has helped
define new 5-HT receptors, increased the understanding of the side effects of numerous …

Serotonin and GI disorders: an update on clinical and experimental studies

M Manocha, WI Khan - Clinical and translational gastroenterology, 2012 - journals.lww.com
The gastrointestinal (GI) tract is the largest producer of serotonin (5-hydroxytryptamine (5-
HT)) in the body, and as such it is intimately connected with GI function and physiology. 5-HT …

Diverse effects of gut-derived serotonin in intestinal inflammation

MS Shajib, A Baranov, WI Khan - ACS Chemical Neuroscience, 2017 - ACS Publications
The gut is the largest producer of serotonin or 5-hydroxytryptamine (5-HT) in the human
body, and 5-HT has been recognized as an important signaling molecule in the gut for …

The diverse metabolic roles of peripheral serotonin

AM Martin, RL Young, L Leong, GB Rogers… - …, 2017 - academic.oup.com
Abstract Serotonin (5-hydroxytryptamine or 5-HT) is a multifunctional bioamine with
important signaling roles in a range of physiological pathways. Almost all of the 5-HT in our …

The role of serotonin and its receptors in activation of immune responses and inflammation

MS Shajib, WI Khan - Acta physiologica, 2015 - Wiley Online Library
Abstract Serotonin or 5‐hydroxytryptamine (5‐HT) is a neurotransmitter and hormone that
contributes to the regulation of various physiological functions by its actions in the central …