[HTML][HTML] Ambient NO2 exposure induces migraine in rats: Evidence, mechanisms and interventions

S Ye, S Li, Y Ma, L Wei, Y Zeng, D Hu, F Xiao - Science of The Total …, 2022 - Elsevier
Migraine is a complex neurological disorder with a high disability rate. Although the
precipitating factors of migraine remain unclear, previous studies suggest that when there is …

Mechanism of NO2-induced migraine in rats: The exploration of the role of miR-653-3p/IGF1 axis

S Ye, L Wei, Y Jiang, Y Yuan, Y Zeng, L Zhu… - Journal of Hazardous …, 2024 - Elsevier
Migraine is a severely disabling primary neurological disorder. Although some studies have
confirmed that nitrogen dioxide (NO 2) pollution increases the risk of migraine, and our …

Increased expression of endothelial and neuronal nitric oxide synthase in dura and pia mater after air stress

T Zinck, R Illum, I Jansen-Olesen - Cephalalgia, 2006 - journals.sagepub.com
Stress is the leading precipitating factor for migraine attacks but the underlying mechanism
is currently unknown. Nitric oxide (NO) has been implicated in migraine pathogenesis based …

Increased nitric oxide stress is associated with migraine

HJ Gruber, C Bernecker, A Lechner, S Weiss… - …, 2010 - journals.sagepub.com
Nitric oxide (NO) has been implicated in migraine attacks, but the role of NO in migraine
remains unclear. We here hypothesize that increased NO in the headache-free period is …

Nitric oxide in migraine

L Neeb, U Reuter - … (Formerly Current Drug Targets-CNS & …, 2007 - ingentaconnect.com
The potent vasodilatator and messenger molecule nitric oxide (NO) is believed to play a key
role in migraine pathogenesis. NO donors such as glyceryl trinitrate (GTN) can cause …

Peroxynitrite contributes to behavioral responses, increased trigeminal excitability, and changes in mitochondrial function in a preclinical model of migraine

J Lackovic, V Jeevakumar, M Burton… - Journal of …, 2023 - Soc Neuroscience
Administration of a nitric oxide (NO) donor triggers migraine attacks, but the mechanisms by
which this occurs are unknown. Reactive nitroxidative species, including NO and …

[HTML][HTML] Rebalancing NOX2/Nrf2 to limit inflammation and oxidative stress across gut-brain axis in migraine

A Ardizzone, AP Capra, A Repici, M Lanza… - Free Radical Biology …, 2024 - Elsevier
Migraine is one of the most common neurological illnesses, and it is characterized by
complicated neurobiology. It was confirmed the influence of inflammation and oxidative …

Delayed inflammation in rat meninges: implications for migraine pathophysiology

U Reuter, H Bolay, I Jansen-Olesen, A Chiarugi… - Brain, 2001 - academic.oup.com
Nitric oxide (NO) has been implicated in migraine pathogenesis based on the delayed
development of typical migraine headache 4–6 h after infusing the NO donor nitroglycerin …

Nitric oxide role in anxiety-like behavior, memory and cognitive impairments in animal model of chronic migraine

P Taheri, F Mohammadi, M Nazeri, MR Zarei… - Heliyon, 2020 - cell.com
The occurrence of cognitive dysfunctions and anxiety and mood disorders has been shown
to be higher in migraine patients. Nitric Oxide (NO) is a significant neurotransmitter in the …

Can nitric oxide induce migraine in normal individuals?

J Olesen, M Ashina - Cephalalgia, 2015 - journals.sagepub.com
Introduction For many years, scientists have debated the possibility that an individual
“migraine threshold” determines the likelihood with which individuals may express migraine …