Senile osteoporosis (SOP) is widely regarded as one of the typical aging-related diseases
due to a decrease in bone mass and the destruction in microarchitecture. The inhibition of …

Senescence of bone marrow mesenchymal stem cells (BMSCs) is one of the leading causes
of osteoporosis. SIRT3, an essential NAD-dependent histone deacetylase, is highly …

Altered mitochondria activity in osteoblasts and osteoclasts has been implicated in the loss
of bone mass associated with aging and estrogen deficiency—the 2 most common causes of …

Oxidative stress is one of the main causes of aging. The process of physiological aging is
always accompanied by increased levels of endogenous oxidative stress. Exogenous …

Osteoporosis is widely regarded as one of the typical aging-related diseases due to the
impairment of bone remodeling. The silent information regulator of transcription1 (SIRT1) is …

Despite recent controversy about their function in some organisms, sirtuins are thought to
play evolutionarily conserved roles in lifespan extension. Whether sirtuins can reverse aging …

ABSTRACT Sirtuin 1 (Sirt1), a protein deacetylase, is a novel target for bone metabolism. To
investigate whether overexpression of Sirt1 in mandibular mesenchymal stem cells (M …

Mesenchymal stem cells (MSCs) are multipotent cells that are currently being investigated in
a wide variety of clinical trials for their anti‐inflammatory and immunomodulatory properties …

Abstract Environmental Cadmium (Cd) is a toxicant with widespread exposure, documented
adverse effects on bone homeostasis, and makes the onset of osteoporosis (OP), one of the …

Mesenchymal stem cells (MSCs) senescence is an age-related process that impairs the
capacity for tissue repair and compromises the clinical use of autologous MSCs for tissue …