Osteoarthritis (OA) is among the most frequent diseases of the musculoskeletal system.
Degradation of cartilage extracellular matrix (ECM) is a hallmark of OA. During the …

Articular cartilage is a connective tissue consisting of a specialized extracellular matrix
(ECM) that dominates the bulk of its wet and dry weight. Type II collagen and aggrecan are …

The articular cartilage covers the end of the long bones and ensures frictionless motion of
the joints. Chondrocytes produce and maintain in a homeostatic equilibrium a large amount …

The extracellular matrix (ECM) has long been viewed primarily as an organized network of
solid-phase ligands for integrin receptors. During degenerative processes, such as …

Understanding biology at the systems level is a powerful method for discovery of previously
unrecognized molecular pathways and mechanisms in human disease. The application of …

Osteoarthritis (OA) is a major cause of disability and socioeconomic loss worldwide.
However, the current pharmacological approaches used to treat OA are largely palliative …

Collagens serve essential mechanical functions throughout the body, particularly in the
connective tissues. In articular cartilage, collagens provide most of the biomechanical …

Osteoarthritis (OA) is a degenerative joint disease that is characterized primarily by
progressive breakdown of articular cartilage. The loss of proteoglycans, the mineralization of …

The extracellular matrix (ECM) of articular cartilage is comprised of complex networks of
proteins and glycoproteins, all of which are expressed by its resident cell, the chondrocyte …

The articular cartilage of synovial joints ensures friction-free mobility and attenuates
mechanical impact on the joint during movement. These functions are mediated by the …