Cartilage extracellular matrix-derived matrikines in osteoarthritis
AE Rapp, F Zaucke - American Journal of Physiology-Cell …, 2023 - journals.physiology.org
Osteoarthritis (OA) is among the most frequent diseases of the musculoskeletal system.
Degradation of cartilage extracellular matrix (ECM) is a hallmark of OA. During the …
Degradation of cartilage extracellular matrix (ECM) is a hallmark of OA. During the …
The minor collagens in articular cartilage
Articular cartilage is a connective tissue consisting of a specialized extracellular matrix
(ECM) that dominates the bulk of its wet and dry weight. Type II collagen and aggrecan are …
(ECM) that dominates the bulk of its wet and dry weight. Type II collagen and aggrecan are …
Role of proteoglycans in osteoarthritis
J Bertrand, A Held - Cartilage: Volume 2: Pathophysiology, 2017 - Springer
The articular cartilage covers the end of the long bones and ensures frictionless motion of
the joints. Chondrocytes produce and maintain in a homeostatic equilibrium a large amount …
the joints. Chondrocytes produce and maintain in a homeostatic equilibrium a large amount …
Matrilin-3 switches from anti-to pro-anabolic upon integration to the extracellular matrix
JB Vincourt, S Etienne, L Grossin, J Cottet… - Matrix Biology, 2012 - Elsevier
The extracellular matrix (ECM) has long been viewed primarily as an organized network of
solid-phase ligands for integrin receptors. During degenerative processes, such as …
solid-phase ligands for integrin receptors. During degenerative processes, such as …
Proteomics makes progress in cartilage and arthritis research
Understanding biology at the systems level is a powerful method for discovery of previously
unrecognized molecular pathways and mechanisms in human disease. The application of …
unrecognized molecular pathways and mechanisms in human disease. The application of …
The regulation of cartilage extracellular matrix homeostasis in joint cartilage degeneration and regeneration
Z Peng, H Sun, V Bunpetch, Y Koh, Y Wen, D Wu… - Biomaterials, 2021 - Elsevier
Osteoarthritis (OA) is a major cause of disability and socioeconomic loss worldwide.
However, the current pharmacological approaches used to treat OA are largely palliative …
However, the current pharmacological approaches used to treat OA are largely palliative …
[HTML][HTML] Cartilage-related collagens in osteoarthritis and rheumatoid arthritis: from pathogenesis to therapeutics
Z Ouyang, L Dong, F Yao, K Wang, Y Chen… - International Journal of …, 2023 - mdpi.com
Collagens serve essential mechanical functions throughout the body, particularly in the
connective tissues. In articular cartilage, collagens provide most of the biomechanical …
connective tissues. In articular cartilage, collagens provide most of the biomechanical …
Molecular mechanisms of cartilage remodelling in osteoarthritis
J Bertrand, C Cromme, D Umlauf, S Frank… - The international journal …, 2010 - Elsevier
Osteoarthritis (OA) is a degenerative joint disease that is characterized primarily by
progressive breakdown of articular cartilage. The loss of proteoglycans, the mineralization of …
progressive breakdown of articular cartilage. The loss of proteoglycans, the mineralization of …
[HTML][HTML] Chondrocyte secretome: a source of novel insights and exploratory biomarkers of osteoarthritis
C Sanchez, AC Bay-Jensen, T Pap… - Osteoarthritis and …, 2017 - Elsevier
The extracellular matrix (ECM) of articular cartilage is comprised of complex networks of
proteins and glycoproteins, all of which are expressed by its resident cell, the chondrocyte …
proteins and glycoproteins, all of which are expressed by its resident cell, the chondrocyte …
[HTML][HTML] Quantitative proteomics at different depths in human articular cartilage reveals unique patterns of protein distribution
C Müller, A Khabut, J Dudhia, FP Reinholt, A Aspberg… - Matrix Biology, 2014 - Elsevier
The articular cartilage of synovial joints ensures friction-free mobility and attenuates
mechanical impact on the joint during movement. These functions are mediated by the …
mechanical impact on the joint during movement. These functions are mediated by the …