Ischemic stroke is the leading cause of death and long-term disability worldwide, and, while
considerable progress has been made in understanding its pathophysiology, the lack of …

Acute neuroprotection in numerous human clinical trials has been an abject failure. Major
systemic-and procedural-based issues have subsequently been identified in both clinical …

Involvement of various neurotransmitters and neuromodulators have been shown to
contribute to the ischemic injury and neuronal death associated with stroke Role of …

Ischemic preconditioning involves a brief exposure to ischemia in order to develop a
tolerance to injurious effects of prolonged ischemia. The molecular mechanisms of …

Neuroprotection aims to prevent salvageable neurons from dying. Despite showing efficacy
in experimental stroke studies, the concept of neuroprotection has failed in clinical trials …

In the area of brain injury and neurodegenerative diseases, a plethora of experimental and
clinical evidence strongly indicates the promise of therapeutically exploiting the endogenous …

Practically any stimulus capable of causing injury to a tissue or organ can, when applied
close to (but below) the threshold of damage, activate endogenous protective mechanisms …

Stroke is one of the leading causes of death and long-term serious disability. Current
therapeutic strategy is limited to thrombolytic agents, consequently, boosting endogenous …

Ischemic tolerance defines transient resistance to lethal ischemia gained by a prior sublethal
noxious stimulus (ie, preconditioning). This adaptive response is thought to be an …

Translational vehicles for neuroprotection Page 1 1318 Biochemical Society Transactions (2006)
Volume 34, part 6 Translational vehicles for neuroprotection M. Papadakis*† and AM …