In the mammalian cochlea, acoustic information is carried to the brain by the predominant
(95%) large-diameter, myelinated type I afferents, each of which is postsynaptic to a single …

Afferent synapses on inner hair cells (IHC) transfer auditory information to the central
nervous system (CNS). Despite the importance of these synapses for normal hearing, their …

Two types of sensory hair cells in the mammalian cochlea signal through anatomically
distinct populations of spiral ganglion afferent neurons. The solitary inner hair cell ribbon …

Type II cochlear afferents receive glutamatergic synaptic excitation from outer hair cells
(OHCs) in the rat cochlea. However, it remains uncertain whether this connection is capable …

The mammalian cochlea is innervated by two classes of sensory neurons. Type I neurons
make up 90–95% of the cochlear nerve and contact single inner hair cells to provide …

Hearing loss among the elderly correlates with diminished social, mental, and physical
health. Age-related cochlear cell death does occur, but growing anatomical evidence …

Extracellular ATP has multimodal actions in the cochlea affecting hearing sensitivity. ATP-
gated ion channels involved in this process were characterized in the guinea pig cochlea …

Cholinergic neurons of the brainstem olivary complex project to and inhibit outer hair cells
(OHCs), refining acoustic sensitivity of the mammalian cochlea. In all vertebrate hair cells …

Outer hair cells in the mammalian cochlea receive a cholinergic efferent innervation that
constitutes the effector arm of a sound-evoked negative feedback loop. The well-studied …

Cochlear outer hair cells (OHCs) serve both as sensory receptors and biological motors.
Their sensory function is poorly understood because their afferent innervation, the type-II …