Abstract Background and Objective Several clinical trials have examined and indicated the
usefulness of epidural dexmedetomidine therapy. However, there has been no systematic …

Purpose This systematic review and meta-analysis appraise the clinical evidence on efficacy
and safety of dexmedetomidine (DEX), as a sedative and analgesic adjunct in adult patients …

Background Several randomized controlled trials (RCTs) have evaluated the use of
dexmedetomidine versus fentanyl as adjuvants to ropivacaine for epidural anaesthesia, yet …

Background Neuraxial application of dexmedetomidine (DEX) as adjuvant analgesic has
been invetigated in some randomized controlled trials (RCTs) but not been approved …

Results: A total of 18 studies met the inclusion criteria. The postoperative heart rate and
mean arterial pressure for the dexmedetomidine group were significantly lower than the …

Background Dexmedetomidine is known to prolong the analgesic duration of spinal
anesthesia, but it can be challenging to achieve further extension without opioids. Therefore …

Purpose To assess the effects of dexmedetomidine on the duration of sensory and motor
block, postoperative analgesia, hypotension, bradycardia, and side effects in patients …

Background Dexmedetomidine has analgesic properties, but the intraoperative analgesic
effect of dexmedetomidine is often masked by the effects of other general anaesthetics …

Background: Dexmedetomidine has been shown to have an analgesic effect. However, no
consensus was reached in previous studies. Methods: Electronic databases such as …

Many nociceptive, inflammatory, and neuropathic pathways contribute to perioperative pain.
Although opioids have long been a mainstay for perioperative analgesia, other non-opioid …