Mitochondria and microbiota dysfunction in COVID-19 pathogenesis

J Saleh, C Peyssonnaux, KK Singh, M Edeas - Mitochondrion, 2020 - Elsevier
The COVID-19 pandemic caused by the coronavirus (SARS-CoV-2) has taken the world by
surprise into a major crisis of overwhelming morbidity and mortality. This highly infectious …

Mitochondria: in the cross fire of SARS-CoV-2 and immunity

J Burtscher, G Cappellano, A Omori, T Koshiba… - IScience, 2020 - cell.com
The pathophysiology, immune reaction, and differential vulnerability of different population
groups and viral host immune system evasion strategies of severe acute respiratory …

SARS-CoV-2 achieves immune escape by destroying mitochondrial quality: comprehensive analysis of the cellular landscapes of lung and blood specimens from …

C Duan, R Ma, X Zeng, B Chen, D Hou, R Liu… - Frontiers in …, 2022 - frontiersin.org
Mitochondria get caught in the crossfire of coronavirus disease 2019 (COVID-19) and
antiviral immunity. The mitochondria-mediated antiviral immunity represents the host's first …

Pathophysiological involvement of host mitochondria in SARS-CoV-2 infection that causes COVID-19: A comprehensive evidential insight

C Bhowal, S Ghosh, D Ghatak, R De - Molecular and cellular biochemistry, 2023 - Springer
SARS-CoV-2 is a positive-strand RNA virus that infects humans through the nasopharyngeal
and oral route causing COVID-19. Scientists left no stone unturned to explore a targetable …

Coronavirus (Covid-19) sepsis: revisiting mitochondrial dysfunction in pathogenesis, aging, inflammation, and mortality

S Shenoy - Inflammation research, 2020 - Springer
Background Decline in mitochondrial function occurs with aging and may increase mortality.
We discuss mitochondrial contribution to Covid-19 sepsis, specifically the complex …

SARS-CoV-2 causes mitochondrial dysfunction and mitophagy impairment

C Shang, Z Liu, Y Zhu, J Lu, C Ge, C Zhang… - Frontiers in …, 2022 - frontiersin.org
Mitochondria, which is essential for adequate innate immune response, energy metabolism
and mitochondria reactive oxygen species (ROS) production, might be in the cross fire of …

[HTML][HTML] SARS-CoV-2 mitochondriopathy in COVID-19 pneumonia exacerbates hypoxemia

SL Archer, A Dasgupta, KH Chen, D Wu, K Baid… - Redox Biology, 2022 - Elsevier
Rationale Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes COVID-
19 pneumonia. We hypothesize that SARS-CoV-2 causes alveolar injury and hypoxemia by …

Possible pathogenesis and prevention of long COVID: SARS-CoV-2-induced mitochondrial disorder

TH Chen, CJ Chang, PH Hung - International journal of molecular …, 2023 - mdpi.com
Patients who have recovered from coronavirus disease 2019 (COVID-19) infection may
experience chronic fatigue when exercising, despite no obvious heart or lung abnormalities …

Core mitochondrial genes are down-regulated during SARS-CoV-2 infection of rodent and human hosts

JW Guarnieri, JM Dybas, H Fazelinia, MS Kim… - Science translational …, 2023 - science.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viral proteins bind to host
mitochondrial proteins, likely inhibiting oxidative phosphorylation (OXPHOS) and stimulating …

Decoding SARS-CoV-2 hijacking of host mitochondria in COVID-19 pathogenesis

KK Singh, G Chaubey, JY Chen… - American Journal of …, 2020 - journals.physiology.org
Because of the ongoing pandemic around the world, the mechanisms underlying the SARS-
CoV-2-induced COVID-19 are subject to intense investigation. Based on available data for …