The self-administration model is the primary non-clinical approach for assessing the
reinforcing properties of novel compounds. Given the now frequent use of rats in self …

Drug self-administration procedures in laboratory settings allow us to closely model drug-
taking behavior in real-world settings. This review provides an overview of many of the …

This paper describes the rationale for use of preclinical assessments of abuse liability in
laboratory animals, and then discusses 'cross-cutting'methodological issues that apply to …

Rationale Laboratory animal and human models of drug self-administration are used to
evaluate potential pharmacotherapies for drug abuse, yet the utility of these models in …

Within the drug development industry the assessment of abuse potential for novel molecules
involves the generation and review of data from multiple sources, ranging from in-vitro …

The purpose of this review is to illustrate the utility and value of employing human self-
administration procedures in medication development, including abuse liability assessments …

In the early 1960s, several investigators demonstrated that opiate dependent rats and
monkeys would repeatedly make responses that resulted in the intravenous delivery of …

This chapter will review the procedures and results of drug self-administration research in
laboratory animals which provide information about the abuse liability of drugs in man. Since …

Drug abuse is a major public health problem, and the relationship between intravenous drug
abuse and AIDS underscores the need for more effective treatment medications. Animal …

A major toxic effect that has limited the clinical usefulness of medicinal drugs has been their
susceptibility to nonmedical use and abuse by significant segments of the population. Major …