Genetics of Familial Hypercholesterolemia (FH) is ascribable to pathogenic variants in
genes encoding proteins leading to an impaired LDL uptake by the LDL receptor (LDLR) …

Familial hypercholesterolemia (FH) is a common genetic disorder of lipid metabolism
caused by pathogenic/likely pathogenic variants in LDLR, APOB, and PCSK9 genes …

Background Familial hypercholesterolemia (FH) is an autosomal dominant disease
characterized by elevated plasma levels of LDL-cholesterol that confers an increased risk of …

Background The familial inherited genetic disorder of lipoprotein metabolism affects more
than 10 million individuals around the world. Lebanon is one of the several endemic areas …

Hypercholesterolemia is a strong determinant of mortality and morbidity associated with
cardiovascular diseases and a major contributor to the global disease burden. Mutations in …

Familial hypercholesterolemia (FH) results from impaired catabolism of plasma low density
lipoproteins (LDL), thus leading to high cholesterol, atherosclerosis, and a high risk of …

Familial hypercholesterolemia (FH) is the most common genetic disease caused by variants
in LDLR, APOB, PCSK9 genes; it is characterized by high levels of LDL‐cholesterol and …

Familial Hypercholesterolaemia is an autosomal, dominant genetic disorder that leads to
elevated blood cholesterol and a dramatically increased risk of atherosclerosis. It is …

Familial hypercholesterolaemia (FH) results from defective catabolism of low density
lipoproteins (LDL), leading to premature atherosclerosis and early coronary heart disease. It …

Atherosclerotic cardiovascular disease is the leading cause of death globally. Despite its
important risk of premature atherosclerosis and cardiovascular disease, familial …