Introduction The aim of this study was to investigate the role of the proinflammatory axis TNF-
α–TNFR1 in experimentally induced periapical inflammation and bone resorption in mice …

Introduction Tumor necrosis factor (TNF)-α is a pro-inflammatory cytokine that promotes
biomineralization in vitro in dental pulp cells. However, the role of TNF-α-TNF receptor 1 …

Apical periodontitis is an inflammatory condition that is considered an immunological
reaction of the periapical tissue to invading bacteria and their pathogenic components …

Inflammatory cytokines contribute to periapical tissue destruction. Their activity is potentially
regulated by suppressors of cytokine signaling (SOCS), which downregulate signal …

Nitric oxide (NO) and reactive oxygen species (ROS) are key molecules in resistance to
pathogens. Little is known about their role in pathogenesis of periapical lesions. To address …

Periodontitis has been advocated as a systematic chronic low-grade infection burden.
However, the relationship between periodontitis and bone defect healing has not been …

Periodontitis is a chronic inflammatory oral disease that affects almost half of the adult
population. NF-κB activator 1 (Act1) is mainly expressed in immune cells, including …

INTRODUCTION: The present study investigated whether bacteria infecting the root canal
can activate any infiltrating T cells to produce receptor activator of nuclear factor kappa B …

Aim To evaluate the relationship between systemic administration of probiotics and
inflammation/resorption processes associated with apical periodontitis (AP) in a rat model …

Abstract Background/Aims: Periapical periodontitis is a common oral disease caused by
bacterial invasion of the tooth pulp, which usually leads to local release of pro-inflammatory …