Clinical significance of interleukin-6 (IL-6) gene polymorphism and IL-6 serum level in pancreatic adenocarcinoma and chronic pancreatitis

R Talar-Wojnarowska, A Gasiorowska… - Digestive diseases and …, 2009 - Springer
The aim of our study was to assess the clinical significance of-174G/C Il-6 gene
polymorphism and Il-6 serum level in patients with pancreatic adenocarcinoma (PA) and …

IL-6-174 C/G polymorphism in the gastroenteropancreatic neuroendocrine tumors (GEP-NETs)

MC Berković, M Jokić, J Marout, S Radošević… - … and molecular pathology, 2007 - Elsevier
IL-6 is a pleiotropic cytokine with still controversial role in tumorigenesis of different cancer
types. Its promoter SNP-174 C/G is associated with increased IL-6 transcription and in some …

174G>C Polymorphism of Interleukin 6 Gene Promoter Affects Interleukin 6 Serum Level in Patients with Colorectal Cancer

C Belluco, F Olivieri, M Bonafè, S Giovagnetti… - Clinical cancer …, 2003 - AACR
Purpose: Experimental data suggest that interleukin 6 (IL-6) plays an important role in the
development and progression of metastasis from colorectal cancer (CRC), and− 174 G> C …

Serum interleukin-6 level but not genotype predicts survival after resection in stages II and III gastric carcinoma

WC Liao, JT Lin, CY Wu, SP Huang, MT Lin… - Clinical cancer …, 2008 - AACR
Purpose: It has been suggested that interleukin-6 (IL-6) is a prognostic indicator for survival
in patients with gastric carcinoma, but this has not been proved using survival analysis. In …

Interleukin-6 polymorphisms and gender: relationship with the occurrence of hepatocellular carcinoma in patients with end-stage liver disease

E Falleti, C Fabris, P Toniutto, E Fontanini, A Cussigh… - Oncology, 2009 - karger.com
Objective: To investigate whether interleukin-6 (IL-6) polymorphisms could be associated
with the occurrence of hepatocellular carcinoma (HCC) in patients with liver cirrhosis and …

Interleukin 1 beta gene promoter SNPs are associated with risk of pancreatic cancer

R Hamacher, S Diersch, M Scheibel, F Eckel, M Mayr… - Cytokine, 2009 - Elsevier
Epidemiological and experimental data demonstrate, that inflammation contributes
significantly to pancreatic carcinogenesis. IL1β, a pleiotropic cytokine produced by …

[HTML][HTML] Interleukin-8, a promising predictor for prognosis of pancreatic cancer

Y Chen, M Shi, GZ Yu, XR Qin, G Jin… - World journal of …, 2012 - ncbi.nlm.nih.gov
AIM: To investigate the value of interleukin-8 (IL-8), a pro-inflammatory chemokine, in
predicting the prognosis of pancreatic cancer. METHODS: Expression of IL-8 and its …

Elevated serum interleukin-6 levels in patients with pancreatic cancer

S Okada, T Okusaka, H Ishii, A Kyogoku… - Japanese journal of …, 1998 - academic.oup.com
The vast majority of pancreatic cancer patients have advanced disease at the time of
diagnosis and they eventually become so emaciated that death primarily occurs from cancer …

IL‐18 serum level and IL‐18 promoter gene polymorphism in Iranian patients with gastrointestinal cancers

MR Haghshenas, SV Hosseini… - Journal of …, 2009 - Wiley Online Library
Abstract Background and Aim: Interleukin (IL)‐18 level and association of its two promoter
gene polymorphisms at− 607C/A and− 137G/C positions were investigated in Iranian …

[HTML][HTML] Genetic association of interleukin-6 polymorphism (-174 G/C) with chronic liver diseases and hepatocellular carcinoma

L Giannitrapani, M Soresi, D Balasus… - World journal of …, 2013 - ncbi.nlm.nih.gov
Abstract Interleukin-6 (IL-6) is a pleiotropic cytokine which is expressed in many
inflammatory cells in response to different types of stimuli, regulating a number of biological …