How hematopoietic stem cells (HSCs) coordinate their divisional axis and whether this
orientation is important for stem cell–driven hematopoiesis is poorly understood. Single-cell …

How hematopoietic stem cells (HSCs) coordinate their divisional axis relative to supportive
niche cells and whether or not their divisional orientation is important for stem cell-driven …

Proper regulation of RNA localization, fidelity and translation are fundamental mechanisms
regulated by RNA-binding proteins (RBPs). Staufen, a double-stranded RBP, mediates …

Early stage myeloid malignancies such as Chronic Myelogenous Leuekemia (CML) and
Myelodysplastic syndrome (MDS) are often indolent and slow growing, but can progress …

Every second, millions of blood cells are generated and destroyed by a mammalian
organism. At the same time, a constant pool of hematopoietic stem cells that are able to self …

Many inherited bone marrow failure syndromes (IBMFSs) present a high risk of
transformation to myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) …

Shwachman–Diamond syndrome (SDS) is an inherited bone marrow failure disorder that
often presents at infancy. Progress has been made in revealing causal mutated genes …

The stem cell–intrinsic model of self-renewal via asymmetric cell division (ACD) posits that
fate determinants be partitioned unequally between daughter cells to either activate or …

Hematopoietic stem cells (HSCs) can self-renew and differentiate for the entire life of an
organism to produce new blood cells when needed. This process is regulated by …