How to contain artemisinin-and multidrug-resistant falciparum malaria

AM Dondorp, FM Smithuis, C Woodrow… - Trends in …, 2017 - cell.com
In the Greater Mekong subregion (GMS), artemisinin resistance is increasingly compounded
by partner drug resistance, causing high failure rates of artemisinin combination therapies in …

The challenge of artemisinin resistance can only be met by eliminating Plasmodium falciparum malaria across the Greater Mekong subregion

C Smith Gueye, G Newby, J Hwang, AA Phillips… - Malaria Journal, 2014 - Springer
Artemisinin-based combinations are currently the most effective anti-malarials and, in
addition to vector control, have led to significant declines in malaria morbidity and mortality …

[HTML][HTML] Safety and effectiveness of mass drug administration to accelerate elimination of artemisinin-resistant falciparum malaria: a pilot trial in four villages of Eastern …

J Landier, L Kajeechiwa, MM Thwin… - Wellcome open …, 2017 - ncbi.nlm.nih.gov
Background: Artemisinin and partner drug-resistant falciparum malaria is expanding over
the Greater Mekong Sub-region (GMS). Eliminating falciparum malaria in the GMS while …

Multidrug-resistant malaria and the impact of mass drug administration

JA Zuber, S Takala-Harrison - Infection and drug resistance, 2018 - Taylor & Francis
Based on the emergence and spread throughout the Greater Mekong Subregion (GMS) of
multiple artemisinin-resistant lineages, the prevalence of multidrug resistance leading to …

[图书][B] Global plan for artemisinin resistance containment (GPARC)

World Health Organization - 2011 - apps.who.int
The goal of the GPARC is to protect ACTs for treatment of P. falciparum malaria. The GPARC
comes at a critical juncture. Artemisinin resistance has been confirmed in a limited area …

Progress towards malaria elimination in the Greater Mekong Subregion: perspectives from the World Health Organization

G Manzoni, R Try, JO Guintran, C Christiansen-Jucht… - Malaria journal, 2024 - Springer
Malaria remains a global health challenge, disproportionately affecting vulnerable
communities. Despite substantial progress, the emergence of anti-malarial drug resistance …

Challenges and prospects for malaria elimination in the Greater Mekong Subregion

L Cui, G Yan, J Sattabongkot, B Chen, Y Cao, Q Fan… - Acta tropica, 2012 - Elsevier
Despite significant improvement in the malaria situation of the Greater Mekong Subregion
(GMS), malaria control for the region continues to face a multitude of challenges. The …

Malaria elimination in the Greater Mekong Subregion: challenges and prospects

L Cui, Y Cao, J Kaewkungwal… - … Elimination: A Leap …, 2018 - books.google.com
Malaria is a significant public health problem and impediment to socioeconomic
development in countries of the Greater Mekong Subregion (GMS), which comprises …

Triple artemisinin-based combination therapies for malaria–a new paradigm?

RW van der Pluijm, C Amaratunga, M Dhorda… - Trends in …, 2021 - cell.com
Recent gains in the fight against malaria are threatened by the emergence and spread of
artemisinin and partner drug resistance in Plasmodium falciparum in the Greater Mekong …

The spread of artemisinin-resistant Plasmodium falciparum in the Greater Mekong subregion: a molecular epidemiology observational study

M Imwong, K Suwannasin, C Kunasol… - The Lancet Infectious …, 2017 - thelancet.com
Background Evidence suggests that the PfKelch13 mutations that confer artemisinin
resistance in falciparum malaria have multiple independent origins across the Greater …