Extracellular matrix remodeling in tumor progression and immune escape: from mechanisms to treatments
Z Yuan, Y Li, S Zhang, X Wang, H Dou, X Yu, Z Zhang… - Molecular cancer, 2023 - Springer
The malignant tumor is a multi-etiological, systemic and complex disease characterized by
uncontrolled cell proliferation and distant metastasis. Anticancer treatments including …
uncontrolled cell proliferation and distant metastasis. Anticancer treatments including …
Extracellular matrix and its therapeutic potential for cancer treatment
J Huang, L Zhang, D Wan, L Zhou, S Zheng… - … and Targeted Therapy, 2021 - nature.com
The extracellular matrix (ECM) is one of the major components of tumors that plays multiple
crucial roles, including mechanical support, modulation of the microenvironment, and a …
crucial roles, including mechanical support, modulation of the microenvironment, and a …
The role of the extracellular matrix and its molecular and cellular regulators in cancer cell plasticity
V Poltavets, M Kochetkova, SM Pitson… - Frontiers in …, 2018 - frontiersin.org
The microenvironment encompasses all components of a tumor other than the cancer cells
themselves. It is highly heterogenous, comprising a cellular component that includes …
themselves. It is highly heterogenous, comprising a cellular component that includes …
The extracellular matrix as hallmark of cancer and metastasis: From biomechanics to therapeutic targets
JJF Sleeboom, GS van Tienderen… - Science translational …, 2024 - science.org
The extracellular matrix (ECM) is essential for cell support during homeostasis and plays a
critical role in cancer. Although research often concentrates on the tumor's cellular aspect …
critical role in cancer. Although research often concentrates on the tumor's cellular aspect …
Regulation of tumor immunity and immunotherapy by the tumor collagen extracellular matrix
DB Flies, S Langermann, C Jensen… - Frontiers in …, 2023 - frontiersin.org
It has been known for decades that the tumor extracellular matrix (ECM) is dysfunctional
leading to loss of tissue architecture and promotion of tumor growth. The altered ECM and …
leading to loss of tissue architecture and promotion of tumor growth. The altered ECM and …
Extracellular matrix in the tumor microenvironment and its impact on cancer therapy
E Henke, R Nandigama, S Ergün - Frontiers in molecular biosciences, 2020 - frontiersin.org
Solid tumors are complex organ-like structures that consist not only of tumor cells but also of
vasculature, extracellular matrix (ECM), stromal, and immune cells. Often, this tumor …
vasculature, extracellular matrix (ECM), stromal, and immune cells. Often, this tumor …
The extracellular matrix: its composition, function, remodeling, and role in tumorigenesis
The extracellular matrix (ECM) is a ubiquitous member of the body and is key to the
maintenance of tissue and organ integrity. Initially thought to be a bystander in many cellular …
maintenance of tissue and organ integrity. Initially thought to be a bystander in many cellular …
The extracellular matrix in tumor progression and metastasis
JA Eble, S Niland - Clinical & experimental metastasis, 2019 - Springer
The extracellular matrix (ECM) constitutes the scaffold of tissues and organs. It is a complex
network of extracellular proteins, proteoglycans and glycoproteins, which form …
network of extracellular proteins, proteoglycans and glycoproteins, which form …
Cancer extracellular matrix proteins regulate tumour immunity
A Gordon-Weeks, AE Yuzhalin - Cancers, 2020 - mdpi.com
Simple Summary The extracellular matrix (ECM) is the acellular part of a tissue, a meshwork
of extracellular material produced and secreted by cells into the surrounding medium. The …
of extracellular material produced and secreted by cells into the surrounding medium. The …
Concepts of extracellular matrix remodelling in tumour progression and metastasis
J Winkler, A Abisoye-Ogunniyan, KJ Metcalf… - Nature …, 2020 - nature.com
Tissues are dynamically shaped by bidirectional communication between resident cells and
the extracellular matrix (ECM) through cell-matrix interactions and ECM remodelling …
the extracellular matrix (ECM) through cell-matrix interactions and ECM remodelling …
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