Fosfomycin resistance mechanisms in Enterobacterales: an increasing threat

V Mattioni Marchetti, J Hrabak, I Bitar - Frontiers in Cellular and …, 2023 - frontiersin.org
Antimicrobial resistance is well-known to be a global health and development threat. Due to
the decrease of effective antimicrobials, re-evaluation in clinical practice of old antibiotics, as …

Mobile fosfomycin resistance genes in Enterobacteriaceae—An increasing threat

K Zurfluh, A Treier, K Schmitt, R Stephan - Microbiologyopen, 2020 - Wiley Online Library
Antimicrobial resistance is one of the major threats to the health and welfare of both humans
and animals. The shortage of new antimicrobial agents has led to the re‐evaluation of old …

Prevalence of fosfomycin resistance and plasmid-mediated fosfomycin-modifying enzymes among carbapenem-resistant Enterobacteriaceae in Zhejiang, China

L Huang, YY Hu, R Zhang - Journal of medical …, 2017 - microbiologyresearch.org
Two hundred and thirty-three nonduplicated clinical isolates of carbapenem-resistant
Enterobacteriaceae were collected from four hospitals in Zhejiang, China. 45.1%(105/233) …

Origin of the plasmid-mediated fosfomycin resistance gene fosA3

R Ito, MP Pacey, RT Mettus… - Journal of …, 2018 - academic.oup.com
Background fosA3 is the most commonly reported plasmid-mediated fosfomycin resistance
gene among Enterobacteriaceae. Objectives To identify the origin of fosA3. Methods The …

High Prevalence and Overexpression of Fosfomycin-Resistant Gene fosX in Enterococcus faecium From China

L Xin, X Xu, Q Shi, R Han, J Wang, Y Guo… - Frontiers in …, 2022 - frontiersin.org
Enterococc i are one of the main causes of gastrointestinal tract infections in the healthcare
system and can develop resistance to fosfomycin through plasmid or chromosomally …

Differences in Fosfomycin Resistance Mechanisms between Pseudomonas aeruginosa and Enterobacterales

D Zheng, PJ Bergen, CB Landersdorfer… - Antimicrobial agents …, 2022 - Am Soc Microbiol
Multidrug-resistant (MDR) Pseudomonas aeruginosa presents a serious threat to public
health due to its widespread resistance to numerous antibiotics. P. aeruginosa commonly …

[HTML][HTML] Update on fosfomycin-modified genes in Enterobacteriaceae

TY Yang, PL Lu, SP Tseng - Journal of Microbiology, Immunology and …, 2019 - Elsevier
The long-used antibiotic fosfomycin has recently been re-evaluated as a potential regimen
for treating extended-spectrum β-lactamases (ESBLs) and carbapenem-resistant …

[HTML][HTML] Molecular mechanisms and epidemiology of fosfomycin resistance in enterococci isolated from patients at a teaching hospital in China, 2013–2016

X Zhang, W Bi, L Chen, Y Zhang, R Fang, J Cao… - Journal of Global …, 2020 - Elsevier
Objectives The aim of this study was to investigate the mechanisms of fosfomycin resistance
and epidemiological characteristics in fosfomycin-resistant enterococci in China. Methods A …

Identification of FosA8, a plasmid-encoded fosfomycin resistance determinant from Escherichia coli, and its origin in Leclercia adecarboxylata

L Poirel, X Vuillemin, N Kieffer, L Mueller… - Antimicrobial agents …, 2019 - Am Soc Microbiol
ABSTRACT A plasmid-located fosfomycin resistance gene, fosA8, was identified from a CTX-
M-15-producing Escherichia coli isolate recovered from urine. Identification of this gene was …

Widespread Fosfomycin Resistance in Gram-Negative Bacteria Attributable to the Chromosomal fosA Gene

R Ito, MM Mustapha, AD Tomich, JD Callaghan… - MBio, 2017 - Am Soc Microbiol
Fosfomycin is a decades-old antibiotic which is being revisited because of its perceived
activity against many extensively drug-resistant Gram-negative pathogens. FosA proteins …