CGRP-based migraine therapeutics: how might they work, why so safe, and what next?
AF Russo - ACS pharmacology & translational science, 2018 - ACS Publications
Migraine is a debilitating neurological condition that involves the neuropeptide calcitonin
gene-related peptide (CGRP). An exciting development is the recent FDA approval of the …
gene-related peptide (CGRP). An exciting development is the recent FDA approval of the …
Targeting CGRP: a new era for migraine treatment
S Wrobel Goldberg, SD Silberstein - CNS drugs, 2015 - Springer
Migraine is a highly prevalent headache disease that typically affects patients during their
most productive years. Despite significant progress in understanding the underlying …
most productive years. Despite significant progress in understanding the underlying …
CGRP monoclonal antibodies for migraine: rationale and progress
Calcitonin gene-related peptide (CGRP), a neuropeptide abundant in the trigeminal system
and widely expressed in both the peripheral and central nervous systems, has recently …
and widely expressed in both the peripheral and central nervous systems, has recently …
CGRP and migraine: the role of blocking calcitonin gene-related peptide ligand and receptor in the management of migraine
K Maasumi, RL Michael, AM Rapoport - Drugs, 2018 - Springer
Migraine is a highly prevalent, complex neurological disorder. The burden of disease and
the direct/indirect annual costs are enormous. Thus far, treatment options have been …
the direct/indirect annual costs are enormous. Thus far, treatment options have been …
Calcitonin gene-related peptide (CGRP)-targeted monoclonal antibodies and antagonists in migraine: current evidence and rationale
Calcitonin gene-related peptide (CGRP), a 37 amino-acid neuropeptide found mostly in
peptidergic sensory C-fibers, has been suggested to be implicated in the pathogenesis of …
peptidergic sensory C-fibers, has been suggested to be implicated in the pathogenesis of …
Blocking CGRP in migraine patients–a review of pros and cons
M Deen, E Correnti, K Kamm, T Kelderman… - The journal of headache …, 2017 - Springer
Migraine is the most prevalent neurological disorder worldwide and it has immense
socioeconomic impact. Currently, preventative treatment options for migraine include drugs …
socioeconomic impact. Currently, preventative treatment options for migraine include drugs …
Mode and site of action of therapies targeting CGRP signaling
A Labastida-Ramírez, E Caronna, C Gollion… - The journal of headache …, 2023 - Springer
Targeting CGRP has proved to be efficacious, tolerable, and safe to treat migraine; however,
many patients with migraine do not benefit from drugs that antagonize the CGRPergic …
many patients with migraine do not benefit from drugs that antagonize the CGRPergic …
Calcitonin gene relating peptide inhibitors in combination for migraine treatment: a mini-review
T Shah, K Bedrin, A Tinsley - Frontiers in Pain Research, 2023 - frontiersin.org
The discovery of calcitonin gene-related peptide (CGRP) and its role in migraine
pathophysiology has led to advances in the treatment of migraine. Since 2018, the Food and …
pathophysiology has led to advances in the treatment of migraine. Since 2018, the Food and …
New trends in migraine pharmacology: targeting calcitonin gene–related peptide (CGRP) with monoclonal antibodies
D Scuteri, A Adornetto, L Rombolà… - Frontiers in …, 2019 - frontiersin.org
Migraine is a common neurologic disorder characterized by attacks consisting of unilateral,
throbbing headache accompanied by photophobia, phonophobia, and nausea which …
throbbing headache accompanied by photophobia, phonophobia, and nausea which …
[HTML][HTML] Targeted CGRP small molecule antagonists for acute migraine therapy
PR Holland, PJ Goadsby - Neurotherapeutics, 2018 - Elsevier
Migraine is a highly prevalent, severe, and disabling neurological condition with a significant
unmet need for effective acute therapies. Patients (~ 50%) are dissatisfied with their currently …
unmet need for effective acute therapies. Patients (~ 50%) are dissatisfied with their currently …