Abstract Changes in DNA methylation in cancer have been heralded as promising targets
for the development of powerful diagnostic, prognostic, and predictive biomarkers. Despite …

Carcinogenesis is accompanied by widespread DNA methylation changes within the cell.
These changes are characterized by a globally hypomethylated genome with focal …

Biomarkers are naturally-occurring characteristics by which a particular pathological process
or disease can be identified or monitored. They can reflect past environmental exposures …

Cellular DNA undergoes profound changes in methylation during cancer development, with
hypermethylation occurring in specific gene promoters, amidst a backdrop of generalized …

DNA methylation based biomarkers have considerable potential for molecular diagnostics,
both as tumor specific biomarkers for the early detection or post-therapeutic monitoring of …

DNA methylation is a highly regulated process that has a critical role in human development
and homeostatic control of the cell. The number of genes affected by anomalous DNA …

Tumor-acquired changes in DNA methylation are the focus of research in an increasing
number of basic, translational, and clinical laboratories around the world. In the laboratory …

DNA methylation is one of the best-known epigenetic modifications in mammals. The
alteration of DNA methylation patterns has been found to be related to many diseases …

In light of the high incidence and mortality rates of cancer, early and accurate diagnosis is an
important priority for assigning optimal treatment for each individual with suspected illness …

DNA methylation occurring on the 5 position of the pyrimidine ring of cytosines in the context
of the dinucleotide sequence CpG forms one of the multiple layers of epigenetic …