Nephropathy is one of the major complications of diabetes which further directs to end stage
renal disease. Extensive work has been done to find out the mechanisms involved in …

At present, diabetic kidney disease affects about 15–25% of type 1 and 30–40% of type 2
diabetic patients. Several decades of extensive research has elucidated various pathways to …

Diabetic nephropathy (DN) is one of the major microvascular complications of diabetes and
one of the leading causes of death among patients with diabetes. DN is characterized by …

Renal cells are a rich source of transforming growth factor (TGF)-β, and they serve as targets
for its actions. Our hypothesis that activation of the TGF-β system in the kidney is implicated …

Diabetes is the major cause of chronic kidney disease which in turn may lead to end-stage
renal disease (ESRD) ending up in dialysis. Hemodynamic and structural changes following …

Diabetic kidney disease is a main cause of end-stage renal disease (ESRD), therefore, it is
important to understand the molecular mechanism underlying diabetic kidney disease …

Over the past 10 years, it has been established that the multifunctional cytokine,
transforming growth factorbeta (TGF-ß) plays a critical role in the development of diabetic …

Diabetic nephropathy is the leading cause of kidney disease in patients starting renal
replacement therapy and affects~ 30% of type 1 and type 2 diabetic patients. This review …

Diabetes is the leading cause of ESRD because diabetic nephropathy develops in 30 to
40% of patients. Diabetic nephropathy does not develop in the absence of hyperglycemia …

Progressive renal injury in diabetes mellitus leads to majormorbidity and mortality. The
manifestations of diabetic nephropathy may bea consequence of the actions of certain …