Many physiological processes, including most kidney-related functions, follow specific
rhythms tied to a 24-h cycle. This is largely because circadian genes operate in virtually …

The circadian clock contributes to the control of BP, but the underlying mechanisms remain
unclear. We analyzed circadian rhythms in kidneys of wild-type mice and mice lacking the …

Many basic physiological functions exhibit circadian rhythmicity. These functional rhythms
are driven, in part, by the circadian clock, an ubiquitous molecular mechanism allowing cells …

Circadian variations in renal function were first described in the 19th century, and GFR, renal
blood flow, urine production, and electrolyte excretion exhibit daily oscillations. These …

Since the kidney is integral to maintenance of fluid and ion homeostasis, and therefore
blood pressure regulation, its proper function is paramount. Circadian fluctuations in blood …

Urinary excretion of water and all major electrolytes exhibit robust circadian oscillations. The
24-h periodicity has been well documented for several important determinants of urine …

Renal excretion of water and major electrolytes exhibits a significant circadian rhythm. This
functional periodicity is believed to result, at least in part, from circadian changes in …

Numerous physiological functions exhibit substantial circadian oscillations. In the kidneys,
renal plasma flow, the glomerular filtration rate and tubular reabsorption and/or secretion …

Circadian rhythms are endogenous biological oscillations that regulate various
physiological processes in organisms, including kidney function. The kidney plays a vital …

Highlights•Regulation of renal function is influenced by the circadian clock.•Dysregulation of
the molecular clock has been linked to worsened kidney disease and hypertension in rodent …