[HTML][HTML] Current Strategies for Increasing Knock-In Efficiency in CRISPR/Cas9-Based Approaches

AF Leal, AM Herreno-Pachón… - International Journal of …, 2024 - mdpi.com
Since its discovery in 2012, the clustered regularly interspaced short palindromic repeats
(CRISPR) and CRISPR-associated protein 9 (Cas9) system has supposed a promising …

Precision genome editing in the CRISPR era

J Salsman, G Dellaire - Biochemistry and cell biology, 2017 - cdnsciencepub.com
With the introduction of precision genome editing using CRISPR–Cas9 technology, we have
entered a new era of genetic engineering and gene therapy. With RNA-guided …

[HTML][HTML] Evolution of CRISPR towards accurate and efficient mammal genome engineering

SM Ryu, JW Hur, K Kim - BMB reports, 2019 - ncbi.nlm.nih.gov
The evolution of genome editing technology based on CRISPR (clustered regularly
interspaced short palindromic repeats) system has led to a paradigm shift in biological …

[HTML][HTML] The potential of CRISPR/Cas9 gene editing as a treatment strategy for inherited diseases

SA Abdelnour, L Xie, AA Hassanin, E Zuo… - Frontiers in cell and …, 2021 - frontiersin.org
Clustered regularly interspaced short palindromic repeats (CRISPR) is a promising
innovative technology for genomic editing that offers scientists the chance to edit DNA …

Recent advances in CRISPR‐Cas9 genome editing technology for biological and biomedical investigations

V Singh, N Gohil, R Ramirez Garcia… - Journal of cellular …, 2018 - Wiley Online Library
ABSTRACT The Type II CRISPR‐Cas9 system is a simple, efficient, and versatile tool for
targeted genome editing in a wide range of organisms and cell types. It continues to gain …

CRISPR-Cas9: a new and promising player in gene therapy

L Xiao-Jie, X Hui-Ying, K Zun-Ping… - Journal of medical …, 2015 - jmg.bmj.com
First introduced into mammalian organisms in 2013, the RNA-guided genome editing tool
CRISPR-Cas9 (clustered regularly interspaced short palindromic repeats/CRISPR …

[HTML][HTML] Advance trends in targeting homology-directed repair for accurate gene editing: An inclusive review of small molecules and modified CRISPR-Cas9 systems

F Shams, H Bayat, O Mohammadian, S Mahboudi… - BioImpacts …, 2022 - ncbi.nlm.nih.gov
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Introduction: Clustered regularly interspaced short palindromic repeat and its associated …

Strategies for enhancing the homology-directed repair efficiency of CRISPR-cas systems

W Sun, H Liu, W Yin, J Qiao, X Zhao, Y Liu - The CRISPR journal, 2022 - liebertpub.com
The CRISPR-Cas nuclease has emerged as a powerful genome-editing tool in recent years.
The CRISPR-Cas system induces double-strand breaks that can be repaired via the non …

[HTML][HTML] CRISPR/Cas9 delivery system engineering for genome editing in therapeutic applications

H Cheng, F Zhang, Y Ding - Pharmaceutics, 2021 - mdpi.com
The clustered regularly interspaced short palindromic repeats (CRISPR)/associated protein
9 (CRISPR/Cas9) systems have emerged as a robust and versatile genome editing platform …

CRISPR/Cas9 technology as a potent molecular tool for gene therapy

A Karimian, K Azizian, H Parsian… - Journal of cellular …, 2019 - Wiley Online Library
Clustered regularly interspaced short palindromic repeats/CRISPR‐associated nuclease 9
(CRISPR‐Cas9) is an RNA‐guided gene editing tool which offers several advantageous …